Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Knoxville Bus Station | Harrisburg Bus Station | CheapestFastest |
Last refresh of the prices: Last Monday at 1:06 PM EST.
Get from Knoxville to Harrisburg
The journey takes about 15 hours 5 minutes and with fares starting at just $99, it presents an excellent value for a comfortable ride.
Where are the popular stops in Knoxville and Harrisburg?
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Stops in Harrisburg
- A
Harrisburg Bieber Greyhound Station
411 Market St, Harrisburg, PA 17101
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Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Knoxville, TN to Harrisburg by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Knoxville to Harrisburg?
The cheapest bus tickets from Knoxville to Harrisburg start from $99. The average price for this route is around $155. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Knoxville to Harrisburg?
The average bus trip duration from Knoxville to Harrisburg is 15h 5m, covering a distance of 480 miles (774 km). The quickest bus can get you there in 15h 5m and is operated by Greyhound.
Which bus companies service the Knoxville to Harrisburg route?
Several major bus companies operate on this route with 1 buses available per day.
What is the earliest and latest departure time for the bus from Knoxville to Harrisburg?
The earliest bus departs from Knoxville to Harrisburg at 7:40pm. And the latest bus departs at 10:50pm.
What are the CO₂ emissions for the bus trip from Knoxville to Harrisburg?
A bus trip from Knoxville to Harrisburg generates an estimated 19 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Knoxville, TN to Harrisburg was searched and found on Jan 29, 2026 with a price of $91To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Harrisburg, as early as possible.
You can expect to pay from $91 to $168 for a bus ticket from Knoxville, TN to Harrisburg based on the last 2 days. You can expect to find the cheapest price for the trip at $91 which is on 2026-01-29.
