How much is the bus ticket from La Crosse to Milwaukee?

The cheapest bus tickets from La Crosse to Milwaukee start from $57. The average price for this route is around $64. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from La Crosse to Milwaukee?

The average bus travel time from La Crosse to Milwaukee is 4h 40m, covering a distance of 283 km. The quickest bus can get you there in 3h 45m and is operated by Jefferson Lines .

Which bus companies service the La Crosse to Milwaukee route?

Several major bus companies operate on this route with 3 buses available per day, including services from Jefferson Lines , Megabus .

What are the earliest and latest departure times for the bus from La Crosse to Milwaukee?

The earliest bus departs from La Crosse to Milwaukee at 2:30pm. And the latest bus departs at 4:10pm.

What are the CO₂ emissions for the bus trip from La Crosse to Milwaukee?

A bus trip from La Crosse to Milwaukee generates an estimated 7 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.

What is the best bus company from La Crosse to Milwaukee?

According to Busbud customers, the highest-rated bus company on this route is Jefferson Lines , with an average rating of 3.9 out of 5 stars based on 759 reviews.

Which bus company has the best Wi-Fi from La Crosse to Milwaukee?

Based on Busbud reviews, the bus company Jefferson Lines has the highest Wi-Fi rating with a score of 3.1.

Which bus company has the best on-time performance from La Crosse to Milwaukee?

According to Busbud traveller reviews, the most punctual bus company on this route is Jefferson Lines , with a punctuality rating of 3.8 out of 5 stars.

Which bus company has the cleanest buses from La Crosse to Milwaukee?

According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Megabus , with a cleanliness rating of 4.3 out of 5 stars.

Bus La Crosse to Milwaukee from $56 | Refundable Tickets

Next bus departures

Next departures for La Crosse to Milwaukee on December 12
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	2:30pm	314 Jay St., La Crosse	3h 50m	6:20pm	St. Paul & N5th	Cheapest
Bus	2:35pm	La Crosse (U of WI)	3h 45m	6:20pm	St. Paul & N5th	Fastest
Bus	4:00pm	La Crosse St Andrew St	4h 50m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	No tags
Bus	4:10pm	La Crosse WI - University of Wisconsin (LSW)	4h 40m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	No tags

Next departures for La Crosse to Milwaukee on December 13
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	2:30pm	314 Jay St., La Crosse	3h 50m	6:20pm	St. Paul & N5th	Cheapest
Bus	2:35pm	La Crosse (U of WI)	3h 45m	6:20pm	St. Paul & N5th	Fastest
Bus	4:00pm	La Crosse St Andrew St	4h 50m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	No tags
Bus	4:10pm	La Crosse WI - University of Wisconsin (LSW)	4h 40m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	No tags

Next departures for La Crosse to Milwaukee on December 14
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Bus	4:00pm	La Crosse St Andrew St	4h 50m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	Cheapest
	Bus	4:10pm	La Crosse WI - University of Wisconsin (LSW)	4h 40m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	Fastest

Next departures for La Crosse to Milwaukee on December 15
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	2:30pm	314 Jay St., La Crosse	3h 50m	6:20pm	St. Paul & N5th	Cheapest
Bus	2:35pm	La Crosse (U of WI)	3h 45m	6:20pm	St. Paul & N5th	Fastest
Bus	4:00pm	La Crosse St Andrew St	4h 50m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	No tags
Bus	4:10pm	La Crosse WI - University of Wisconsin (LSW)	4h 40m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	No tags

Next departures for La Crosse to Milwaukee on December 16
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	2:30pm	314 Jay St., La Crosse	3h 50m	6:20pm	St. Paul & N5th	Cheapest
Bus	2:35pm	La Crosse (U of WI)	3h 45m	6:20pm	St. Paul & N5th	Fastest
Bus	4:00pm	La Crosse St Andrew St	4h 50m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	No tags
Bus	4:10pm	La Crosse WI - University of Wisconsin (LSW)	4h 40m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	No tags

Next departures for La Crosse to Milwaukee on December 17
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	2:30pm	314 Jay St., La Crosse	3h 50m	6:20pm	St. Paul & N5th	Cheapest
Bus	2:35pm	La Crosse (U of WI)	3h 45m	6:20pm	St. Paul & N5th	Fastest
Bus	4:00pm	La Crosse St Andrew St	4h 50m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	No tags
Bus	4:10pm	La Crosse WI - University of Wisconsin (LSW)	4h 40m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	No tags

Next departures for La Crosse to Milwaukee on December 18
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	2:30pm	314 Jay St., La Crosse	3h 50m	6:20pm	St. Paul & N5th	Cheapest
Bus	2:35pm	La Crosse (U of WI)	3h 45m	6:20pm	St. Paul & N5th	Fastest
Bus	4:00pm	La Crosse St Andrew St	4h 50m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	No tags
Bus	4:10pm	La Crosse WI - University of Wisconsin (LSW)	4h 40m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	No tags

Last refresh of the prices: Today at 1:57 PM CST.

Compare 2 ways to go from La Crosse to Milwaukee

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach Milwaukee. The journey takes about 4 hours 40 minutes, and with fares starting at just $57, it presents an excellent value for a comfortable ride.

3bus per day

4h 40mAverage Duration

283 kmDistance

7kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$57 - $80	Average Duration4h 40m	CO₂ emissions 7kg CO₂e
Train	Average Price$37 - $181	Average Duration3h 36m	CO₂ emissions 26kg CO₂e

Compare bus companies

Jefferson Lines

4/5759 reviews

Staff4

Timeliness3.8

Cleanliness4

Wifi3.2

Based on 759 reviews, the company was rated 3.9 stars on Busbud. Travellers were especially satisfied with the temperature and the seats but often complained with the WiFi. Jefferson Lines ticket prices on this trip start at $57

Jefferson Lines La Crosse Milwaukee recent customer reviews

confusing instructions to where the bus would pick me up, made me miss my bus. awful return exchange policy, so i cant do anything about it

Kaitlyn S.

January 30, 2022

Megabus

3.5/5414 reviews

Staff4.1

Timeliness3.7

Cleanliness4.3

Wifi2.4

US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Big Sky

Frequently asked questions about travelling from La Crosse, WI to Milwaukee by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from La Crosse to Milwaukee?
The cheapest bus tickets from La Crosse to Milwaukee start from $57. The average price for this route is around $64. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from La Crosse to Milwaukee?
The average bus travel time from La Crosse to Milwaukee is 4h 40m, covering a distance of 283 km. The quickest bus can get you there in 3h 45m and is operated by Jefferson Lines.
Which bus companies service the La Crosse to Milwaukee route?
Several major bus companies operate on this route with 3 buses available per day, including services from Jefferson Lines, Megabus.
What are the earliest and latest departure times for the bus from La Crosse to Milwaukee?
The earliest bus departs from La Crosse to Milwaukee at 2:30pm. And the latest bus departs at 4:10pm.
What are the CO₂ emissions for the bus trip from La Crosse to Milwaukee?
A bus trip from La Crosse to Milwaukee generates an estimated 7 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from La Crosse to Milwaukee?
According to Busbud customers, the highest-rated bus company on this route is Jefferson Lines, with an average rating of 3.9 out of 5 stars based on 759 reviews.
Which bus company has the best Wi-Fi from La Crosse to Milwaukee?
Based on Busbud reviews, the bus company Jefferson Lines has the highest Wi-Fi rating with a score of 3.1.
Which bus company has the best on-time performance from La Crosse to Milwaukee?
According to Busbud traveller reviews, the most punctual bus company on this route is Jefferson Lines, with a punctuality rating of 3.8 out of 5 stars.
Which bus company has the cleanest buses from La Crosse to Milwaukee?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Megabus, with a cleanliness rating of 4.3 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

12-08

$61

12-09

$61

Today

$61

12-11

$61

12-12

$61

12-13

$61

12-14

$61

12-15

$61

The cheapest trip from La Crosse, WI to Milwaukee was searched and found on Dec 8, 2025 with a price of $61

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Crosse, WI to Milwaukee, as early as possible.

You can expect to pay from $61 to $77 for a bus ticket from La Crosse, WI to Milwaukee based on the last 2 days. You can expect to find the cheapest price for the trip at $61 which is on 2025-12-11.