Bus from Orlando to Greenville, SC: Tickets & Schedules

Next bus departures

Next departures for Orlando to Greenville on November 29
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBusBus
Orlando Bus Station
1116 Woodruff RdCheapest
Greyhound Lines, Inc.Bus
Orlando Bus Station
1116 Woodruff RdFastest
FlixBusBus
Orlando Bus Station
1116 Woodruff RdNo tags
FlixBus + Greyhound Lines, Inc.
Bus
Orlando Bus Station
1116 Woodruff RdNo tags
FlixBus + Greyhound Lines, Inc.
Bus
The Florida Mall
1116 Woodruff RdNo tags

Last refresh of the prices: Last Tuesday at 9:25 AM EST.

Compare 2 ways to go from Orlando to Greenville

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 11 hours 55 minutes, and with fares starting at just $99, it presents an excellent value for a comfortable ride.

5bus per day
11h 55mAverage Duration
704 kmDistance
18kgCO₂ emissions
Average Price$99 - $294Average Duration11h 55m
18kg CO₂e
Average Price$239 - $1,495Average Duration1d 10h
65kg CO₂e

Frequently asked questions about travelling from Orlando to Greenville, SC by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

  1. How much is the bus ticket from Orlando to Greenville?

    The cheapest bus tickets from Orlando to Greenville start from $99. The average price for this route is around $153. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

  2. How long is the bus ride from Orlando to Greenville?

    The average bus travel time from Orlando to Greenville is 11h 55m, covering a distance of 704 km. The quickest bus can get you there in 10h 25m and is operated by Greyhound.

  3. Which bus companies service the Orlando to Greenville route?

    Several major bus companies operate on this route with 5 buses available per day, including services from FlixBus, Greyhound.

  4. What are the earliest and latest departure times for the bus from Orlando to Greenville?

    The earliest bus departs from Orlando to Greenville at 4:45am. And the latest bus departs at 10:55pm.

  5. What are the CO₂ emissions for the bus trip from Orlando to Greenville?

    A bus trip from Orlando to Greenville generates an estimated 18 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.

  6. What is the best bus company from Orlando to Greenville?

    According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 11380 reviews.

  7. Which bus company has the best Wi-Fi from Orlando to Greenville?

    Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.

  8. Which bus company has the best on-time performance from Orlando to Greenville?

    According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.

  9. Which bus company has the cleanest buses from Orlando to Greenville?

    According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
11-26
$212
11-27
$145
Today
No data
11-29
$184
11-30
$257
12-01
$166
12-02
$152
12-03
$124
busbud logoThe cheapest trip from Orlando to Greenville, SC was searched and found on Dec 3, 2025 with a price of $124

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Orlando to Greenville, SC, as early as possible.

You can expect to pay from $124 to $314 for a bus ticket from Orlando to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at $124 which is on 2025-12-03.

Usually FlixBus, Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

What's the cheapest way to go from Orlando to Greenville, SC?

busbud logoThe bus is the cheapest travel choice for this destination

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