Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Orlando Bus Station | Gateway Station | Cheapest | ||||
 | Bus | Orlando Bus Station | Gateway Station | Fastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Orlando Bus Station | Gateway Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | The Florida Mall | Gateway Station | No tags |
Last refresh of the prices: Yesterday at 4:27 PM EST.
Compare 2 ways to go from Orlando to St. Louis
Among the sustainable travel choices, the bus stands out as a good way to reach St. Louis. The journey takes about 1 day, 2 hours, and with fares starting at just $146, it presents an excellent value for a comfortable ride.
Where are the popular stops in Orlando and St. Louis?
Stops in Orlando
- A555 N John Young Pkwy, Orlando, FL 32805
- BRedCoach Station, 1777 McCoy Road, Orlando, FL 32809
- CJet Set Express Terminal, 3718 LB Mcleod Rd., 32805 Orlando, FL,, United States
- D
Disney World
Disney's All-Star Sports Resort, 1701 West Buena Vista Dr., Orlando, FL 32830 - E
International Dr SuperTours Terminal
5419 International Dr, Orlando, FL 32819, USA - F
Seaworld Hotels
10100 International Drive , Orlando, 32821
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Frequently asked questions about travelling from Orlando to St. Louis by bus
How far is Orlando from St. Louis?
It's about 1388 km (861 miles) from Orlando to St. Louis.
What are the departure and arrival locations for buses traveling from Orlando to St. Louis?
Buses departing from Orlando Bus Station in Orlando will take you to Gateway Station in St. Louis.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Orlando to St. Louis was searched and found on Nov 28, 2025 with a price of $170To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Orlando to St. Louis, as early as possible.
You can expect to pay from $170 to $332 for a bus ticket from Orlando to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $170 which is on 2025-11-28.
Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Orlando to St. Louis?
The bus is the cheapest travel choice for this destination
