Next departures for Philadelphia to St. Louis on November 23
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Philadelphia, 199 Spring Garden St
Gateway Station
Cheapest
FlixBus + Greyhound Lines, Inc.
Bus
Philadelphia, 199 Spring Garden St
Gateway Station
Fastest
Bus
199 Spring Garden St.
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Cherry Hill Mall
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Philadelphia (Logan Square)
Gateway Station
No tags
Next departures for Philadelphia to St. Louis on November 24
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
199 Spring Garden St.
Gateway Station
Cheapest
Bus
199 Spring Garden St.
Gateway Station
Fastest
Bus
199 Spring Garden St.
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Philadelphia, 199 Spring Garden St
Gateway Station
No tags
Bus
199 Spring Garden St.
Gateway Station
No tags
Next departures for Philadelphia to St. Louis on November 26
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
199 Spring Garden St.
Gateway Station
Cheapest
Bus
199 Spring Garden St.
Gateway Station
Fastest
Bus
199 Spring Garden St.
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Philadelphia, 199 Spring Garden St
Gateway Station
No tags
Bus
199 Spring Garden St.
Gateway Station
No tags
Last refresh of the prices: Today at 8:43 AM EST.
Compare 2 ways to go from Philadelphia to St. Louis
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as a good way to reach St. Louis. The journey takes about 1 day, 3 hours 55 minutes, and with fares starting at just $100, it presents an excellent value for a comfortable ride.
Based on 87391 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $100
Greyhound Philadelphia St. Louis recent customer reviews
Based on 11414 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the WiFi. FlixBus ticket prices on this trip start at $139
Frequently asked questions about travelling from Philadelphia, PA to St. Louis by bus
How far is Philadelphia from St. Louis?
The distance covered from Philadelphia to St. Louis is 1303 km (808 miles).
What are the departure and arrival locations for buses traveling from Philadelphia to St. Louis?
Buses traveling this route start their trip at Philadelphia Airport, in Philadelphia, and end it at Gateway Station, in St. Louis.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11-21
$203
11-22
$180
Today
$180
11-24
$186
11-25
No data
11-26
$236
11-27
$174
11-28
$180
The cheapest trip from Philadelphia, PA to St. Louis was searched and found on Nov 27, 2025 with a price of $174
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Philadelphia, PA to St. Louis, as early as possible.
You can expect to pay from $174 to $431 for a bus ticket from Philadelphia, PA to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $174 which is on 2025-11-27.
What's the cheapest way to go from Philadelphia, PA to St. Louis?
The bus is the cheapest travel choice for this destination
The cheapest trip from Philadelphia, PA to St. Louis was searched and found on Nov 27, 2025 with a price of $174
The bus is the cheapest travel choice for this destination
