Next departures for Philadelphia to St. Louis on November 22
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
199 Spring Garden St.
Gateway Station
CheapestFastest
Bus
199 Spring Garden St.
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Philadelphia, 199 Spring Garden St
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Philadelphia, 199 Spring Garden St
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Cherry Hill Mall
Gateway Station
No tags
Next departures for Philadelphia to St. Louis on November 23
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
199 Spring Garden St.
Gateway Station
Cheapest
Bus
199 Spring Garden St.
Gateway Station
Fastest
Bus
199 Spring Garden St.
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Philadelphia, 199 Spring Garden St
Gateway Station
No tags
Bus
199 Spring Garden St.
Gateway Station
No tags
Next departures for Philadelphia to St. Louis on November 26
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
199 Spring Garden St.
Gateway Station
Cheapest
Bus
199 Spring Garden St.
Gateway Station
Fastest
Bus
199 Spring Garden St.
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Philadelphia, 199 Spring Garden St
Gateway Station
No tags
Bus
199 Spring Garden St.
Gateway Station
No tags
Last refresh of the prices: Yesterday at 10:55 PM EST.
Compare 2 ways to go from Philadelphia to St. Louis
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as the good way to reach St. Louis. The journey takes about 1 day, 3 hours 55 minutes and with fares starting at just $69, it presents an excellent value for a comfortable ride.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Philadelphia St. Louis recent customer reviews
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Philadelphia, PA to St. Louis by bus
How far is Philadelphia from St. Louis?
About 808 miles (1303 km) separate Philadelphia and St. Louis.
What are the departure and arrival stations when taking the bus from Philadelphia to St. Louis?
Most of the buses traveling from Philadelphia to St. Louis leave from Philadelphia Airport and arrive at Gateway Station. These are the main departure and arrival locations on this route, but you can also find other options that could better fit your plans.
What are the best sights and things to do in St. Louis?
Once in St. Louis, you can start exploring the city and discover its surroundings. The top sights and things to do are Municipal Theatre Association, St. Louis Cardinals, Citygarden Sculpture Park, Ulysses S. Grant National Historic Site and Scott Joplin House State Historic Site.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/20
$106
11/21
$140
Today
$124
11/23
$110
11/24
No data
11/25
No data
11/26
$163
11/27
$120
The cheapest trip from Philadelphia, PA to St. Louis was searched and found on Nov 20, 2025 with a price of $106
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Philadelphia, PA to St. Louis, as early as possible.
You can expect to pay from $106 to $298 for a bus ticket from Philadelphia, PA to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $110 which is on 2025-11-23.
What's the cheapest way to go from Philadelphia, PA to St. Louis?
The bus is the cheapest travel choice for this destination
The cheapest trip from Philadelphia, PA to St. Louis was searched and found on Nov 20, 2025 with a price of $106
The bus is the cheapest travel choice for this destination
