What is the distance between Pittsburgh and Chicago?

The distance between Pittsburgh and Chicago is approximately 661 km (410 miles).

What are the departure and arrival locations for buses traveling from Pittsburgh to Chicago?

Buses departing from Intermodal Station in Pittsburgh will take you to Downtown Greyhound Station in Chicago.

Bus Pittsburgh to Chicago from $77 | Refundable Tickets

Next bus departures

Next departures for Pittsburgh to Chicago on November 23
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	7:45pm	Pittsburgh Intermodal Station	11h 25m	6:10am	Downtown Greyhound Station	Cheapest
	Bus	12:40am	Pittsburgh Intermodal Station	10h 20m	10:00am	Downtown Greyhound Station	Fastest
	Bus	1:35am	Pittsburgh Intermodal Station	14h	2:35pm	Downtown Greyhound Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	12:40am	Pittsburgh Intermodal Station	13h 45m	1:25pm	Chicago 95Th & Dan Ryan	No tags
	Bus	7:45pm	Pittsburgh Intermodal Station	10h 55m	5:40am	Chicago 95Th & Dan Ryan	No tags

Next departures for Pittsburgh to Chicago on November 24
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	7:40am	Pittsburgh Intermodal Station	13h 25m	8:05pm	Downtown Greyhound Station	Cheapest
	Bus	12:40am	Pittsburgh Intermodal Station	10h 20m	10:00am	Downtown Greyhound Station	Fastest
	Bus	1:35am	Pittsburgh Intermodal Station	14h	2:35pm	Downtown Greyhound Station	No tags
	Bus	7:45pm	Pittsburgh Intermodal Station	11h 25m	6:10am	Downtown Greyhound Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	12:40am	Pittsburgh Intermodal Station	13h 45m	1:25pm	Chicago 95Th & Dan Ryan	No tags

Next departures for Pittsburgh to Chicago on November 25
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	8:40am	Pittsburgh Intermodal Station	12h 25m	8:05pm	Downtown Greyhound Station	Cheapest
	Bus	12:40am	Pittsburgh Intermodal Station	10h 20m	10:00am	Downtown Greyhound Station	Fastest
	Bus	1:35am	Pittsburgh Intermodal Station	14h	2:35pm	Downtown Greyhound Station	No tags
	Bus	7:45pm	Pittsburgh Intermodal Station	11h 25m	6:10am	Downtown Greyhound Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	12:40am	Pittsburgh Intermodal Station	13h 45m	1:25pm	Chicago 95Th & Dan Ryan	No tags

Next departures for Pittsburgh to Chicago on November 26
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	7:45pm	Pittsburgh Intermodal Station	11h 25m	6:10am	Downtown Greyhound Station	Cheapest
	Bus	12:40am	Pittsburgh Intermodal Station	10h 20m	10:00am	Downtown Greyhound Station	Fastest
	Bus	1:35am	Pittsburgh Intermodal Station	14h	2:35pm	Downtown Greyhound Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	12:40am	Pittsburgh Intermodal Station	13h 45m	1:25pm	Chicago 95Th & Dan Ryan	No tags
	Bus	7:45pm	Pittsburgh Intermodal Station	10h 55m	5:40am	Chicago 95Th & Dan Ryan	No tags

Next departures for Pittsburgh to Chicago on November 27
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	7:45pm	Pittsburgh Intermodal Station	11h 25m	6:10am	Downtown Greyhound Station	Cheapest
	Bus	12:40am	Pittsburgh Intermodal Station	10h 20m	10:00am	Downtown Greyhound Station	Fastest
	Bus	1:35am	Pittsburgh Intermodal Station	14h	2:35pm	Downtown Greyhound Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	12:40am	Pittsburgh Intermodal Station	13h 45m	1:25pm	Chicago 95Th & Dan Ryan	No tags
	Bus	7:45pm	Pittsburgh Intermodal Station	10h 55m	5:40am	Chicago 95Th & Dan Ryan	No tags

Next departures for Pittsburgh to Chicago on November 28
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	7:40am	Pittsburgh Intermodal Station	13h 25m	8:05pm	Downtown Greyhound Station	Cheapest
	Bus	12:40am	Pittsburgh Intermodal Station	10h 20m	10:00am	Downtown Greyhound Station	Fastest
	Bus	1:35am	Pittsburgh Intermodal Station	14h	2:35pm	Downtown Greyhound Station	No tags
	Bus	7:45pm	Pittsburgh Intermodal Station	11h 25m	6:10am	Downtown Greyhound Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	12:40am	Pittsburgh Intermodal Station	13h 45m	1:25pm	Chicago 95Th & Dan Ryan	No tags

Next departures for Pittsburgh to Chicago on November 29
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	12:40am	Pittsburgh Intermodal Station	10h 20m	10:00am	Downtown Greyhound Station	CheapestFastest
	Bus	1:35am	Pittsburgh Intermodal Station	14h	2:35pm	Downtown Greyhound Station	No tags
	Bus	7:45pm	Pittsburgh Intermodal Station	11h 25m	6:10am	Downtown Greyhound Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	12:40am	Pittsburgh Intermodal Station	13h 45m	1:25pm	Chicago 95Th & Dan Ryan	No tags
	Bus	7:40am	Pittsburgh Intermodal Station	13h 25m	8:05pm	Downtown Greyhound Station	No tags

Last refresh of the prices: Today at 2:15 PM EST.

Compare 2 ways to go from Pittsburgh to Chicago

We recommend taking the train

Among the sustainable travel choices, the train stands out as a good way to reach Chicago. The journey takes about 9 hours 46 minutes, and with fares starting at just $76, it presents an excellent value for a comfortable ride.

1train per day

9h 46mAverage Duration

660 kmDistance

60kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$80 - $317	Average Duration13h 35m	CO₂ emissions 16kg CO₂e
Train	Average Price$76 - $273	Average Duration9h 46m	CO₂ emissions 60kg CO₂e

Where are the popular stops in Pittsburgh and Chicago?

Stops in Pittsburgh

A
Intermodal Station
55 11th St, Pittsburgh, PA 15222, USA
Visit page
B
Sennott Square
201 S Bouquet St, Pittsburgh, PA 15213, USA

Stops in Chicago

A
Downtown Greyhound Station
630 W Harrison St, Chicago, IL 60607, USA
Visit page
B
Chicago O'Hare International Airport
Visit page
C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA
D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA
E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA
F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA

Compare bus companies

Greyhound

3.5/587,388 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

FlixBus

3.5/511,404 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about travelling from Pittsburgh to Chicago by bus

What is the distance between Pittsburgh and Chicago?
The distance between Pittsburgh and Chicago is approximately 661 km (410 miles).
What are the departure and arrival locations for buses traveling from Pittsburgh to Chicago?
Buses departing from Intermodal Station in Pittsburgh will take you to Downtown Greyhound Station in Chicago.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11-20

$147

11-21

$253

Today

$175

11-23

$151

11-24

$126

11-25

$175

11-26

$119

11-27

$102

The cheapest trip from Pittsburgh to Chicago was searched and found on Nov 27, 2025 with a price of $102

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Pittsburgh to Chicago, as early as possible.

You can expect to pay from $102 to $332 for a bus ticket from Pittsburgh to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $102 which is on 2025-11-27.

Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.