Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | San Antonio Bus Station | Downtown Transit Center | Cheapest | ||||
Greyhound Lines Mexico + Greyhound Lines, Inc. | Bus | San Antonio Bus Station | Indianapolis Bus Station | Fastest | ||||
Greyhound Lines Mexico + Greyhound Lines, Inc. | Bus | San Antonio Bus Station | Indianapolis Bus Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | San Antonio Bus Station | Indianapolis Bus Station | No tags | ||||
Valley Transit + Greyhound Lines, Inc. | Bus | San Antonio Bus Station | Indianapolis Bus Station | No tags |
Last refresh of the prices: Yesterday at 8:37 PM CST.
Compare 2 ways to go from San Antonio to Indianapolis
Among the sustainable travel choices, the bus stands out as a good way to reach Indianapolis. The journey takes about 1 day, 6 hours 30 minutes, and with fares starting at just $182, it presents an excellent value for a comfortable ride.
Where are the popular stops in San Antonio and Indianapolis?
Stops in San Antonio
- A500 N St Mary's St, San Antonio, TX 78205, USA
- B7914 Interstate 35 Access Rd, San Antonio, TX 78224, USA
- C165 Bowie St, San Antonio, 78205
- D4407 S PanAm Expy #101, San Antonio, TX 78225, USA
Compare bus companies
Frequently asked questions about travelling from San Antonio, US to Indianapolis by bus
What is the travel distance from San Antonio to Indianapolis?
The distance covered from San Antonio to Indianapolis is 1611 km (999 miles).
What are the departure and arrival locations for buses traveling from San Antonio to Indianapolis?
Buses traveling this route start their trip at San Antonio Bus Station, in San Antonio, and end it at Greyhound Amtrak Station, in Indianapolis.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Antonio, US to Indianapolis was searched and found on Dec 1, 2025 with a price of $241To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Antonio, US to Indianapolis, as early as possible.
You can expect to pay from $241 to $518 for a bus ticket from San Antonio, US to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at $241 which is on 2025-12-01.
What's the cheapest way to go from San Antonio, US to Indianapolis?
The bus is the cheapest travel choice for this destination
