Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines Mexico + Greyhound Lines, Inc. + FlixBus | Bus | San Antonio Bus Station | Downtown Transit Center | Cheapest | ||||
Greyhound Lines Mexico + Greyhound Lines, Inc. | Bus | San Antonio Bus Station | Indianapolis Bus Station | Fastest | ||||
Greyhound Lines Mexico + Greyhound Lines, Inc. | Bus | San Antonio Bus Station | Indianapolis Bus Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | San Antonio Bus Station | Indianapolis Bus Station | No tags | ||||
 | Bus | San Antonio Bus Station | Indianapolis Bus Station | No tags |
Last refresh of the prices: Last Thursday at 2:34 AM CST.
Compare 2 ways to go from San Antonio to Indianapolis
Among the sustainable travel choices, the Bus stands out as a good way to reach Indianapolis. The journey takes about 1 day, 6 hours 30 minutes, and with fares starting at just $160, it presents an excellent value for a comfortable ride.
Where are the popular stops in San Antonio and Indianapolis?
Stops in San Antonio
- A500 N St Mary's St, San Antonio, TX 78205, USA
- B7914 Interstate 35 Access Rd, San Antonio, TX 78224, USA
- C4407 S PanAm Expy #101, San Antonio, TX 78225, USA
- D165 Bowie St, San Antonio, 78205
Stops in Indianapolis
- A350 S Illinois St, Indianapolis, IN 46225
Compare bus companies
Frequently asked questions about travelling from San Antonio, US to Indianapolis by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from San Antonio to Indianapolis?
The cheapest bus tickets from San Antonio to Indianapolis start from $160. The average price for this route is around $282. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from San Antonio to Indianapolis?
The average bus travel time from San Antonio to Indianapolis is 1d 6h, covering a distance of 1608 km. The quickest bus can get you there in 1d 2h and is operated by Greyhound.
Which bus companies service the San Antonio to Indianapolis route?
Several major bus companies operate on this route with 13 buses available per day, including services from Greyhound, Valley Transit, FlixBus.
What are the earliest and latest departure times for the bus from San Antonio to Indianapolis?
The earliest bus departs from San Antonio to Indianapolis at 1:30am. And the latest bus departs at 9:15pm.
What are the CO₂ emissions for the bus trip from San Antonio to Indianapolis?
A bus trip from San Antonio to Indianapolis generates an estimated 40 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from San Antonio to Indianapolis?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87463 reviews.
Which bus company has the best Wi-Fi from San Antonio to Indianapolis?
Based on Busbud reviews, the bus company Valley Transit has the highest Wi-Fi rating with a score of 2.8.
Which bus company has the best on-time performance from San Antonio to Indianapolis?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from San Antonio to Indianapolis?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Antonio, US to Indianapolis was searched and found on Jan 14, 2026 with a price of $223To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Antonio, US to Indianapolis, as early as possible.
You can expect to pay from $223 to $354 for a bus ticket from San Antonio, US to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at $223 which is on 2026-01-14.
What's the cheapest way to go from San Antonio, US to Indianapolis?
The Bus is the cheapest travel choice for this destination
