Find coaches from Harrisburg to Charleston, SC, US

Find affordable coach tickets from Harrisburg to Charleston, SC, US with flexible options. Book your journey now

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Today3 Aug
from US$140
Tomorrow4 Aug
from US$146
Tue5 Aug
Wed6 Aug
from US$141
Thu7 Aug
from US$156
Fri8 Aug
from US$153
Sat9 Aug
Sun10 Aug

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: 4 August at
    Departure city: Harrisburg
    Departure location: Harrisburg
    Arrival time: 5 August at
    Destination city: Charleston
    Destination location: 4565 Gaynor Ave, North Charleston
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: 4 August at
    Departure city: Harrisburg
    Departure location: Harrisburg Bus Station
    Arrival time: 5 August at
    Destination city: Charleston
    Destination location: 4565 Gaynor Ave, North Charleston
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: 4 August at
    Departure city: Harrisburg
    Departure location: Harrisburg Bus Station
    Arrival time: 5 August at
    Destination city: Charleston
    Destination location: 4565 Gaynor Ave, North Charleston
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: 4 August at
    Departure city: Harrisburg
    Departure location: Harrisburg
    Arrival time: 5 August at
    Destination city: Charleston
    Destination location: 4565 Gaynor Ave, North Charleston
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: 4 August at
    Departure city: Harrisburg
    Departure location: Harrisburg Bus Station
    Arrival time: 5 August at
    Destination city: Charleston
    Destination location: 4565 Gaynor Ave, North Charleston
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:

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Compare 2 ways to travel from Harrisburg to Charleston

Bus
Average priceUS$85 - US$283Average duration1d
22kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average priceUS$165 - US$404Average duration15h 43m
79kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the bus from Harrisburg to Charleston

Among the sustainable travel choices, the bus stands out as a good way to reach Charleston. The journey takes about 1 day, 35 minutes and with fares starting at just US$85, it presents an excellent value for a comfortable ride.

3bus per day
1d Average duration
US$85Cheapest ticket
22kgCO₂ emissions

Bus Harrisburg to Charleston, SC, US: Trip Overview

Average ticket priceUS$139
Average bus trip duration1d
Number of daily buses3
Earliest bus departure10:25
Distance538 miles
Latest bus departure15:05

Harrisburg to Charleston Bus

With Busbud, comparing and booking tickets for a bus from Harrisburg to Charleston is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from Harrisburg to Charleston will be provided by the most trusted bus companies.

Whether it is cheap bus tickets or more luxurious buses going to Charleston from Harrisburg, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Harrisburg - Charleston, SC, US

  1. What's the distance between Harrisburg and Charleston by coach?

    The distance between Harrisburg and Charleston by coach is approximately 544 miles (878 km).

  2. How can I travel from Harrisburg to Charleston avoiding air travel?

    You have the option to select the coach for your journey on this route. The coach ensures a pleasant travel experience, granting you the opportunity to appreciate the scenery as you make your way to your final stop. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
01/08
US$275
02/08
US$187
Today
US$161
04/08
US$201
05/08
US$156
06/08
US$175
07/08
US$188
08/08
US$179
busbud logoThe cheapest trip from Harrisburg to Charleston, SC, US was searched and found on 5 Aug 2025 with a price of US$156

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Harrisburg to Charleston, SC, US as early as possible.

You can expect to pay from US$156 to US$275 for a bus ticket from Harrisburg to Charleston, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$156, which is on 2025-08-05.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Harrisburg to Charleston.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from Harrisburg to Charleston, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Harrisburg to Charleston.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Harrisburg to Charleston.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

What's the cheapest way to go from Harrisburg to Charleston, SC, US?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Harrisburg by bus?

Bus from Harrisburg to Charleston, SC, US

You can also go to Charleston, SC, US by train

Train from Harrisburg to Charleston, SC, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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Popular Buses Connecting Charleston

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