Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Harrisburg Bus Station | 4565 Gaynor Ave, North Charleston | Cheapest | |||||
FlixBus + Greyhound Lines, Inc. | Harrisburg | 4565 Gaynor Ave, North Charleston | Fastest | |||||
Greyhound Lines, Inc. + FlixBus | Harrisburg Bus Station | 4565 Gaynor Ave, North Charleston | No tags | |||||
 | Harrisburg | 4565 Gaynor Ave, North Charleston | No tags |
Last refresh of the prices: Yesterday at 7:58 PM EDT.
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Compare 2 ways to go from Harrisburg to Charleston
Busbud recommends taking the bus from Harrisburg to CharlestonAmong the sustainable travel choices, the bus stands out as a good way to reach Charleston. The journey takes about 1 day, 25 minutes, and with fares starting at just US$75, it presents an excellent value for a comfortable ride.
Bus Harrisburg to Charleston, SC, US: Trip Overview
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Harrisburg to Charleston Bus
With Busbud, comparing and booking tickets for a bus from Harrisburg to Charleston is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
Bus service from Harrisburg to Charleston will be provided by the most trusted bus companies.
Whether it is cheap bus tickets or more luxurious buses going to Charleston from Harrisburg, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in Harrisburg and Charleston?
Frequently asked questions on the trip Harrisburg - Charleston, SC, US
How far is Harrisburg from Charleston?
The distance between Harrisburg and Charleston is around 878 km (544 miles).
What are the departure and arrival locations for buses traveling from Harrisburg to Charleston?
Buses traveling this route start their trip at Harrisburg Bieber Greyhound Station, in Harrisburg, and end it at Charleston Bus Station, in Charleston.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Harrisburg to Charleston, SC, US was searched and found on Sep 25, 2025 with a price of US$79To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Harrisburg to Charleston, SC, US, as early as possible.
You can expect to pay from US$79 to US$165 for a bus ticket from Harrisburg to Charleston, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$79 which is on 2025-09-25.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while travelling from Harrisburg to Charleston.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
Much more than a mere vehicle taking you from Harrisburg to Charleston, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Harrisburg to Charleston.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Harrisburg to Charleston.
Did you know?
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
9.2% of ground transportation in Europe is done by bus versus 7.4% by train.
The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.
What's the cheapest way to go from Harrisburg to Charleston, SC, US?
The bus is the cheapest travel choice for this destinationTop travelled bus routes
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Popular Buses Connecting Harrisburg
Buses Leaving from Harrisburg
- Bus from Harrisburg to Houston
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Buses Going to Harrisburg
- Bus from Pittsburgh to Harrisburg
- Bus Marathon - Harrisburg
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- Bus Temple - Harrisburg
- Orlando - Harrisburg
- Bus from Allentown to Harrisburg
- Bus Philadelphia - Harrisburg
- Lawrence - Harrisburg
- Bus from Wilkes-Barre to Harrisburg
- Bus New York City - Harrisburg
- Syracuse - Harrisburg
- Bus from Dover to Harrisburg
- Bus Newark - Harrisburg
- Columbus - Harrisburg
Popular Buses Connecting Charleston
Buses Leaving from Charleston
- Bus from Charleston to Baltimore
- Bus Charleston - Tulsa
- Charleston - Atlanta
- Bus from Charleston to Fort Worth
- Bus Charleston - Miami
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- Bus Charleston - Las Vegas
- Charleston - Greensboro
- Bus from Charleston to Key Largo
- Bus Charleston - Springfield
- Charleston - Raleigh
Buses Going to Charleston
- Bus from Baltimore to Charleston
- Bus Boston - Charleston
- Greenville - Charleston
- Bus from Raleigh to Charleston
- Bus Nashville - Charleston
- Los Angeles - Charleston
- Bus from Buffalo to Charleston
- Bus Savannah - Charleston
- Las Vegas - Charleston
- Bus from Newark to Charleston
- Bus Philadelphia - Charleston
- Mount Laurel - Charleston
- Bus from New Orleans to Charleston
- Bus Austin - Charleston
- Bangor - Charleston
Popular routes in this country
- Bus from Boston to New York City
- Bus Washington - New York City
- New York City - Boston
- Bus from Buffalo to New York City
- Bus Philadelphia - New York City
- Niagara Falls - New York City
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- Bus Detroit - Chicago
- Baton Rouge - New Orleans
- Bus from Albany to New York City
- Bus Los Angeles - San Francisco
- Miami - Orlando
- Bus from Las Vegas to Los Angeles
- Bus Atlanta - Savannah
- Los Angeles - San Diego