Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Harrisburg Bus Station | Chicago 95Th & Dan Ryan | Cheapest | ||||
 | Bus | Harrisburg Bus Station | Downtown Greyhound Station | Fastest | ||||
| Bus | Harrisburg Bus Station | Downtown Greyhound Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Harrisburg Bus Station | Chicago 95Th & Dan Ryan | No tags | ||||
| Bus | Harrisburg Bus Station | Downtown Greyhound Station | No tags |
Last refresh of the prices: Today at 15:16 EST.
Compare 2 ways to travel from Harrisburg to Chicago
Among the sustainable travel choices, the bus stands out as a good way to reach Chicago. The journey takes about 18 hours 10 minutes and with fares starting at just £53, it presents an excellent value for a comfortable ride.
Where are the popular stops in Harrisburg and Chicago?
Stops in Harrisburg
- A
Harrisburg Bieber Greyhound Station
411 Market St, Harrisburg, PA 17101
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Compare bus companies
Frequently asked questions about travelling by bus from Harrisburg to Chicago
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Harrisburg to Chicago?
The cheapest coach tickets from Harrisburg to Chicago start from £53. The average price for this route is around £100. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Harrisburg to Chicago?
The average bus journey time from Harrisburg to Chicago is 18h 10m, covering a distance of 571 miles. The fastest bus can take you there in 14h 45m and is operated by Greyhound.
Which bus companies service the Harrisburg to Chicago route?
What is the earliest and latest departure time for the bus from Harrisburg to Chicago?
The earliest bus departs from Harrisburg to Chicago at 02:30. And the latest bus departs at 20:15.
What are the CO₂ emissions for the bus trip from Harrisburg to Chicago?
A bus journey from Harrisburg to Chicago produces an estimated 23 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Which is the best bus company from Harrisburg to Chicago?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87387 reviews.
Which company has the best Wi-Fi from Harrisburg to Chicago?
Based on Busbud reviews, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company offers the most punctual service from Harrisburg to Chicago?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Harrisburg to Chicago?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Harrisburg to Chicago was searched and found on 3 Dec 2025 with a price of £66To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Harrisburg to Chicago as early as possible.
You can expect to pay from £66 to £269 for a bus ticket from Harrisburg to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at £66, which is on 2025-12-03.
Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Harrisburg to Chicago?
The bus is the cheapest travel choice for this destination
