Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Harrisburg Bus Station | Downtown Greyhound Station | Cheapest | ||||
 | Bus | Harrisburg Bus Station | Downtown Greyhound Station | Fastest | ||||
| Bus | Harrisburg Bus Station | Downtown Greyhound Station | No tags | ||||
| Bus | Harrisburg Bus Station | Chicago 95Th & Dan Ryan | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Harrisburg Bus Station | Chicago 95Th & Dan Ryan | No tags |
Last refresh of the prices: Yesterday at 11:42 AM EST.
Compare 2 ways to go from Harrisburg to Chicago
Among the sustainable travel choices, the bus stands out as a good way to reach Chicago. The journey takes about 18 hours 10 minutes, and with fares starting at just $97, it presents an excellent value for a comfortable ride.
Where are the popular stops in Harrisburg and Chicago?
Stops in Harrisburg
- A
Harrisburg Bieber Greyhound Station
411 Market St, Harrisburg, PA 17101
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Compare bus companies
Frequently asked questions about travelling from Harrisburg to Chicago by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Harrisburg to Chicago?
The cheapest bus tickets from Harrisburg to Chicago start from $97. The average price for this route is around $197. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Harrisburg to Chicago?
The average bus travel time from Harrisburg to Chicago is 18h 10m, covering a distance of 920 km. The quickest bus can get you there in 14h 45m and is operated by Greyhound.
Which bus companies service the Harrisburg to Chicago route?
What are the earliest and latest departure times for the bus from Harrisburg to Chicago?
The earliest bus departs from Harrisburg to Chicago at 2:30am. And the latest bus departs at 9:10pm.
What are the CO₂ emissions for the bus trip from Harrisburg to Chicago?
A bus trip from Harrisburg to Chicago generates an estimated 23 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Harrisburg to Chicago?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87387 reviews.
Which bus company has the best Wi-Fi from Harrisburg to Chicago?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Harrisburg to Chicago?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Harrisburg to Chicago?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Harrisburg to Chicago was searched and found on Dec 7, 2025 with a price of $118To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Harrisburg to Chicago, as early as possible.
You can expect to pay from $118 to $433 for a bus ticket from Harrisburg to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $118 which is on 2025-12-07.
Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Harrisburg to Chicago?
The bus is the cheapest travel choice for this destination
