Next departures for Harrisburg to Chicago on November 24
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Harrisburg Bus Station
Downtown Greyhound Station
Cheapest
Bus
Harrisburg Bus Station
Downtown Greyhound Station
Fastest
Bus
Harrisburg Bus Station
537-517 W. Jackson Blvd
No tags
Bus
Harrisburg Bus Station
Chicago 95Th & Dan Ryan
No tags
Greyhound Lines, Inc. + FlixBus
Bus
Harrisburg Bus Station
Chicago 95Th & Dan Ryan
No tags
Next departures for Harrisburg to Chicago on November 25
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Harrisburg Bus Station
Downtown Greyhound Station
Cheapest
Bus
Harrisburg Bus Station
Downtown Greyhound Station
Fastest
Bus
Harrisburg Bus Station
Downtown Greyhound Station
No tags
Bus
Harrisburg Bus Station
Chicago 95Th & Dan Ryan
No tags
Greyhound Lines, Inc. + FlixBus
Bus
Harrisburg Bus Station
Chicago 95Th & Dan Ryan
No tags
Next departures for Harrisburg to Chicago on November 26
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Harrisburg Bus Station
Downtown Greyhound Station
Cheapest
Bus
Harrisburg Bus Station
Downtown Greyhound Station
Fastest
Bus
Harrisburg Bus Station
Downtown Greyhound Station
No tags
Bus
Harrisburg Bus Station
Chicago 95Th & Dan Ryan
No tags
Greyhound Lines, Inc. + FlixBus
Bus
Harrisburg Bus Station
Chicago 95Th & Dan Ryan
No tags
Last refresh of the prices: Yesterday at 9:26 AM EST.
Compare 2 ways to go from Harrisburg to Chicago
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as the good way to reach Chicago. The journey takes about 18 hours 10 minutes and with fares starting at just $64, it presents an excellent value for a comfortable ride.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Harrisburg to Chicago by bus
What is the travel distance from Harrisburg to Chicago?
Harrisburg and Chicago are 571 miles (920 km) apart.
What are the departure and arrival stations when taking the bus from Harrisburg to Chicago?
The majority of buses traveling from Harrisburg to Chicago start their journey at Harrisburg Bieber Greyhound Station and wind up at Downtown Greyhound Station. These are the most popular pick-up and drop-off locations on this route, but you could find others that could be a better fit for your travel plans.
What are the best sights and things to do in Chicago?
Once in Chicago, you can start exploring the city and discover its surroundings. The top sights and things to do are Lake Michigan, Lincoln Park Conservatory, Shedd Aquarium, Lincoln Park Zoo and Museum of Science and Industry.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/22
$150
11/23
$125
Today
$121
11/25
$170
11/26
$107
11/27
$98
11/28
$104
11/29
$166
The cheapest trip from Harrisburg to Chicago was searched and found on Nov 27, 2025 with a price of $98
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Harrisburg to Chicago, as early as possible.
You can expect to pay from $98 to $315 for a bus ticket from Harrisburg to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $98 which is on 2025-11-27.
Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Harrisburg to Chicago?
The bus is the cheapest travel choice for this destination
The cheapest trip from Harrisburg to Chicago was searched and found on Nov 27, 2025 with a price of $98
The bus is the cheapest travel choice for this destination
