Find coaches from Port Saint Lucie to Jacksonville, FL

Next departures

Next departures from Port Saint Lucie to Jacksonville on 9 October
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc.
Port St. Lucie (Park & Ride)
Jacksonville Bus StationCheapest
FlixBus
Port St. Lucie (Park & Ride)
Jacksonville Bus StationFastest

Last refresh of the prices: Today at 13:02 EDT.

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus Port Saint Lucie to Jacksonville, FL: Trip Overview

Average ticket priceUS$43
Average bus trip duration6h 5m
Number of daily buses2
Earliest bus departure01:40
Distance225 miles
Latest bus departure15:45

Port Saint Lucie to Jacksonville Bus

Busbud helps you find a bus from Port Saint Lucie to Jacksonville. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from Port Saint Lucie to Jacksonville from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to Jacksonville from Port Saint Lucie, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Port Saint Lucie - Jacksonville, FL

  1. How far is Jacksonville from Port Saint Lucie by coach?

    The distance between Port Saint Lucie and Jacksonville by coach is approximately 225 miles (362 km).

  2. Is there a way to reach Jacksonville from Port Saint Lucie without a car?

    You can travel to Jacksonville from Port Saint Lucie by coach, which provides a smooth ride and an affordable and convenient trip. You can also consider rideshare services depending on your preferences.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06/10
US$38
07/10
US$37
Today
US$37
09/10
US$38
10/10
US$44
11/10
US$43
12/10
US$39
13/10
US$43
busbud logoThe cheapest trip from Port Saint Lucie to Jacksonville, FL was searched and found on 7 Oct 2025 with a price of US$37

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Port Saint Lucie to Jacksonville, FL as early as possible.

You can expect to pay from US$37 to US$73 for a bus ticket from Port Saint Lucie to Jacksonville, FL based on the last 2 days. You can expect to find the cheapest price for the trip at US$38, which is on 2025-10-09.

Usually FlixBus, Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Port Saint Lucie and Jacksonville!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Port Saint Lucie to Jacksonville, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Port Saint Lucie to Jacksonville.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Port Saint Lucie to Jacksonville.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Will you be returning to Port Saint Lucie by bus?

Bus from Jacksonville, FL to Port Saint Lucie

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

‌

Popular Buses Connecting Port Saint Lucie

Buses Leaving from Port Saint Lucie

Buses Going to Port Saint Lucie

Popular Buses Connecting Jacksonville

Buses Leaving from Jacksonville

Buses Going to Jacksonville