What is the travel distance from Port Saint Lucie to Jacksonville?

About 225 miles (362 km) separate Port Saint Lucie and Jacksonville.

What are the departure and arrival stations when taking the bus from Port Saint Lucie to Jacksonville?

The majority of buses traveling from Port Saint Lucie to Jacksonville start their journey at Port St Lucie Mobil Gas Bus Stop and wind up at Jacksonville Amtrak Station. These are the main departure and arrival locations on this route, but you can find others that could fit better into your travel plans.

Bus Port Saint Lucie to Jacksonville from $34 | Refundable Tickets

Previously seen trips

Next departures for Port Saint Lucie to Jacksonville on November 21
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	1:40am	Port St Lucie (Park & Ride)	6h 5m	7:45am	Jacksonville Bus Station	No tags
Bus	8:55am	Port St Lucie (Park & Ride)	6h 5m	3:00pm	Jacksonville Bus Station	No tags
Bus	1:40am	Port St Lucie (Park & Ride)	6h 5m	7:45am	Jacksonville Bus Station	No tags
Bus	8:55am	Port St Lucie (Park & Ride)	6h 5m	3:00pm	Jacksonville Bus Station	No tags
Bus	8:55am	Port St Lucie (Park & Ride)	6h 30m	3:25pm	Jacksonville Bus Station	No tags

Get from Port Saint Lucie to Jacksonville

This route is served by bus only

The journey takes about 6 hours 5 minutes and with fares starting at just $40, it presents an excellent value for a comfortable ride.

2bus per day

6h 5mAverage Duration

225 milesDistance

9kgCO₂ emissions

Where are the popular stops in Port Saint Lucie and Jacksonville?

Stops in Port Saint Lucie

A
Port St Lucie Mobil Gas Bus Stop
1820 Sw Fountainview Blvd, Port Saint Lucie, FL 34986
Visit page
B
Port Saint Lucie - Wendys
1790 SW St Lucie W Blvd, Port St Lucie, FL 34986
C
Port Saint LucieService Plaza
Florida's Turnpike, Milepost 144, Port St Lucie, FL 34984, USA
D
Port Saint Lucie Bus Stop
2198 SW Gatlin Blvd. Port St. Lucie, FL 34953

Stops in Jacksonville

A
Jacksonville Amtrak Station
3570 Clifford Ln, Jacksonville, FL 32209, USA
Visit page
B
W Forsyth St
1111 W Forsyth St, Jacksonville, FL 32204, USA
C
Kings Avenue Station
1003 Kings Avenue, Jacksonville, FL 32207
D
JRTC Greyhound Bus Station
111 W. Forsyth St, Jacksonville, FL 32202, USA

Compare bus companies

FlixBus

3.5/511,389 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

Greyhound

3.5/587,387 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about traveling from Port Saint Lucie to Jacksonville, FL by bus

What is the travel distance from Port Saint Lucie to Jacksonville?
What are the departure and arrival stations when taking the bus from Port Saint Lucie to Jacksonville?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/19

$41

11/20

$47

Today

$51

11/22

$46

11/23

No data

11/24

No data

11/25

$53

11/26

$60

The cheapest trip from Port Saint Lucie to Jacksonville, FL was searched and found on Nov 19, 2025 with a price of $41

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Port Saint Lucie to Jacksonville, FL, as early as possible.

You can expect to pay from $41 to $89 for a bus ticket from Port Saint Lucie to Jacksonville, FL based on the last 2 days. You can expect to find the cheapest price for the trip at $46 which is on 2025-11-22.

Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.