Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Downtown SD (Seaport) | Downtown Transit Center | Cheapest | |||||
FlixBus + Greyhound Lines, Inc. | UCSD Health La Jolla Station | Indianapolis Bus Station | Fastest | |||||
FlixBus + Greyhound Lines, Inc. | San Diego (Old Town-FlixBus) | Indianapolis Bus Station | No tags | |||||
 | Greyhound Bus Stop | Indianapolis Bus Station | No tags | |||||
FlixBus + Greyhound Lines, Inc. | San Diego (Old Town-FlixBus) | Indianapolis Bus Station | No tags |
Last refresh of the prices: Last Friday at 01:20 PST.
Compare 2 ways to travel from San Diego to Indianapolis
Among the sustainable travel choices, the bus stands out as a good way to reach Indianapolis. The journey takes about 2 days, 8 hours 5 minutes and with fares starting at just £203, it presents an excellent value for a comfortable ride.
Where are the popular stops in San Diego and Indianapolis?
Stops in San Diego
- A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA - B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA - C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA - D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA - E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA - F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA
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Frequently asked questions about travelling by bus from San Diego, CA, US to Indianapolis
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from San Diego to Indianapolis?
The cheapest coach tickets from San Diego to Indianapolis start from £203. The average price for this route is around £277. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from San Diego to Indianapolis?
The average bus journey time from San Diego to Indianapolis is 2d 8h, covering a distance of 1783 miles. The fastest bus can take you there in 2d 1h and is operated by FlixBus.
Which bus companies service the San Diego to Indianapolis route?
What is the earliest and latest departure time for the bus from San Diego to Indianapolis?
The earliest bus departs from San Diego to Indianapolis at 06:45. And the latest bus departs at 19:35.
What are the CO₂ emissions for the bus trip from San Diego to Indianapolis?
A bus journey from San Diego to Indianapolis produces an estimated 72 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Which is the best bus company from San Diego to Indianapolis?
According to Busbud customers, the highest-rated bus company on this route is Amtrak, with an average rating of 4.1 out of 5 stars based on 5696 reviews.
Which company has the best Wi-Fi from San Diego to Indianapolis?
Based on Busbud reviews, the bus company Amtrak has the best Wi-Fi rating with a score of 3.6.
Which bus company offers the most punctual service from San Diego to Indianapolis?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from San Diego to Indianapolis?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Amtrak, with a cleanliness rating of 4.5 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Diego, CA, US to Indianapolis was searched and found on 4 Jan 2026 with a price of £232To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to Indianapolis as early as possible.
You can expect to pay from £232 to £736 for a bus ticket from San Diego, CA, US to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at £232, which is on 2026-01-10.
Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from San Diego, CA, US to Indianapolis?
The Bus is the cheapest travel choice for this destination
