- Antofagasta to Santiago buses
Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link | 
|---|---|---|---|---|---|---|---|---|
|  | Terminal Antofagasta | Terminal de Buses San Borja - San Francisco de Borja | Cheapest | |||||
|  | Terminal Carlos Oviedo Cavada | San Borja | Fastest | |||||
|  | Terminal Antofagasta | Terminal de Buses San Borja - San Francisco de Borja | No tags | |||||
|  | Terminal Antofagasta | San Borja | No tags | |||||
|  | Terminal Carlos Oviedo Cavada | San Borja | No tags | 
Last refresh of the prices: Yesterday at 6:47 PM -03.
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Get from Antofagasta to Santiago
The journey takes about 18 hours 15 minutes, and with fares starting at just US$27, it presents an excellent value for a comfortable ride.
Bus Antofagasta to Santiago, CL: Trip Overview
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Antofagasta to Santiago Bus
With Busbud, comparing and booking tickets for a bus from Antofagasta to Santiago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
Bus service from Antofagasta to Santiago will be provided by the most trusted bus companies.
Discover how much the bus trip from Antofagasta to Santiago will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.
Where are the popular stops in Antofagasta and Santiago?
Frequently asked questions on the trip Antofagasta - Santiago, CL
- How much does a bus ticket from Antofagasta to Santiago cost?- The bus ticket price from Antofagasta to Santiago starts at US$27. The best way to find cheap bus tickets from Antofagasta to Santiago is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices! 
- How long is the bus ride from Antofagasta to Santiago?- The average travel time between Antofagasta and Santiago is around 18h 15m, although the fastest bus will take about 17h. This is the time it takes to travel the 1091 km that separates the two cities. 
- How many daily bus connections are there between Antofagasta and Santiago?- The number of buses from Antofagasta to Santiago can differ depending on the day of the week. On average, there are 39 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Antofagasta to Santiago by comparing and selecting the bus that fits your travel style and budget on Busbud. 
- Which bus companies travel from Antofagasta to Santiago?- When taking the bus from Antofagasta to Santiago, you can travel comfortably and safely with Pluss Chile, Pullman San Andres, Cikbus Elité. 
- What are the departure and arrival stations when taking the bus from Antofagasta to Santiago?- Buses travelling between Antofagasta and Santiago leave from Av. Pedro Aguirre Cerda, 253 or Terminal Antofagasta and arrive at San Borja, Terminal Sur, Terminal Los Héroes. 
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Antofagasta to Santiago, CL as early as possible.
You can expect to pay from US$26 to US$52 for a bus ticket from Antofagasta to Santiago, CL based on the last 2 days. You can expect to find the cheapest price for the trip at US$26, which is on 2025-11-01.
Usually Pluss Chile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while travelling from Antofagasta to Santiago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
Much more than a mere vehicle taking you from Antofagasta to Santiago, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.
Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Antofagasta to Santiago will emit half the CO2 emitted by a train, and radically less than a car or an airplane.
Make a music playlist for your bus ride from Antofagasta to Santiago, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.
9.2% of ground transportation in Europe is done by bus versus 7.4% by train.
Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.
Top travelled bus routes
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Popular Buses Connecting Antofagasta
Buses Leaving from Antofagasta
- Bus from Antofagasta to Santiago
- Coach Antofagasta - Sierra Gorda
- Bus Antofagasta - Tocopilla
- Bus from Antofagasta to Coquimbo
- Coach Antofagasta - Vallenar
- Bus Antofagasta - Iquique
- Bus from Antofagasta to Ovalle
- Coach Antofagasta - Vina del Mar
- Bus Antofagasta - Caldera
- Bus from Antofagasta to Calama
- Coach Antofagasta - San Antonio
- Bus Antofagasta - Pichidangui
- Bus from Antofagasta to Copiapo
- Coach Antofagasta - La Serena
- Bus Antofagasta - Pullalli
Buses Going to Antofagasta
- Bus from Iquique to Antofagasta
- Coach Santiago - Antofagasta
- Bus Tocopilla - Antofagasta
- Bus from Sierra Gorda to Antofagasta
- Coach Taltal - Antofagasta
- Bus Calama - Antofagasta
- Bus from Vallenar to Antofagasta
- Coach Caldera - Antofagasta
- Bus Pozo Almonte - Antofagasta
- Bus from Los Vilos to Antofagasta
- Coach Puerto Montt - Antofagasta
- Bus Ovalle - Antofagasta
- Bus from Arica Province to Antofagasta
- Coach Temuco - Antofagasta
- Bus Alto Hospicio - Antofagasta
Popular Buses Connecting Santiago
Buses Leaving from Santiago
- Bus from Santiago to Puerto Montt
- Coach Santiago - Concepción
- Bus Santiago - Antofagasta
- Bus from Santiago to La Serena
- Coach Santiago - Temuco
- Bus Santiago - Mendoza
- Bus from Santiago to Vilcún
- Coach Santiago - Parral
- Bus Santiago - Labranza
- Bus from Santiago to Choshuenco
- Coach Santiago - Lanco
- Bus Santiago - Curacavi
- Bus from Santiago to Litueche
- Coach Santiago - Pinto
- Bus Santiago - Quirihue
Buses Going to Santiago
- Bus from Victoria to Santiago
- Coach Concepción - Santiago
- Bus Castro - Santiago
- Bus from Valdivia to Santiago
- Coach Mendoza - Santiago
- Bus Antofagasta - Santiago
- Bus from Lago Ranco to Santiago
- Coach Cholchol - Santiago
- Bus Chiguayante - Santiago
- Bus from Taltal to Santiago
- Coach Bulnes - Santiago
- Bus Parral - Santiago
- Bus from Teodoro Schmidt to Santiago
- Coach Melipeuco - Santiago
- Bus Talcahuano - Santiago



