Find coaches from Antofagasta to Santiago, CL

Next departures

Next departures from Antofagasta to Santiago on 1 November
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Cikbus Elité
Terminal Antofagasta
Terminal de Buses San Borja - San Francisco de BorjaCheapest
Pullman San Andrés
Terminal Carlos Oviedo Cavada
San BorjaFastest
Cikbus Elité
Terminal Antofagasta
Terminal de Buses San Borja - San Francisco de BorjaNo tags
Pluss Chile
Terminal Antofagasta
San BorjaNo tags
Pullman San Andrés
Terminal Carlos Oviedo Cavada
San BorjaNo tags

Last refresh of the prices: Yesterday at 6:47 PM -03.

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Get from Antofagasta to Santiago

busbud logoThis route is served by bus only

The journey takes about 18 hours 15 minutes, and with fares starting at just US$27, it presents an excellent value for a comfortable ride.

39bus per day
18h 15mAverage duration
1095 kmDistance
27kgCO₂ emissions

Bus Antofagasta to Santiago, CL: Trip Overview

Average ticket priceUS$47
Average bus trip duration18h 15m
Number of daily buses39
Earliest bus departure00:15
Distance1094 km
Latest bus departure23:50

Antofagasta to Santiago Bus

With Busbud, comparing and booking tickets for a bus from Antofagasta to Santiago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from Antofagasta to Santiago will be provided by the most trusted bus companies.

Discover how much the bus trip from Antofagasta to Santiago will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Antofagasta - Santiago, CL

  1. How much does a bus ticket from Antofagasta to Santiago cost?

    The bus ticket price from Antofagasta to Santiago starts at US$27. The best way to find cheap bus tickets from Antofagasta to Santiago is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

  2. How long is the bus ride from Antofagasta to Santiago?

    The average travel time between Antofagasta and Santiago is around 18h 15m, although the fastest bus will take about 17h. This is the time it takes to travel the 1091 km that separates the two cities.

  3. How many daily bus connections are there between Antofagasta and Santiago?

    The number of buses from Antofagasta to Santiago can differ depending on the day of the week. On average, there are 39 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Antofagasta to Santiago by comparing and selecting the bus that fits your travel style and budget on Busbud.

  4. Which bus companies travel from Antofagasta to Santiago?

    When taking the bus from Antofagasta to Santiago, you can travel comfortably and safely with Pluss Chile, Pullman San Andres, Cikbus Elité.

  5. What are the departure and arrival stations when taking the bus from Antofagasta to Santiago?

    Buses travelling between Antofagasta and Santiago leave from Av. Pedro Aguirre Cerda, 253 or Terminal Antofagasta and arrive at San Borja, Terminal Sur, Terminal Los Héroes.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
29/10
US$41
30/10
US$41
Today
US$33
01/11
US$26
02/11
US$37
03/11
US$26
04/11
US$26
05/11
US$26
busbud logoThe cheapest trip from Antofagasta to Santiago, CL was searched and found on 01 Nov 2025 with a price of US$26

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Antofagasta to Santiago, CL as early as possible.

You can expect to pay from US$26 to US$52 for a bus ticket from Antofagasta to Santiago, CL based on the last 2 days. You can expect to find the cheapest price for the trip at US$26, which is on 2025-11-01.

Usually Pluss Chile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Antofagasta to Santiago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from Antofagasta to Santiago, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Antofagasta to Santiago will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

Make a music playlist for your bus ride from Antofagasta to Santiago, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

Will you be returning to Antofagasta by bus?

Bus from Santiago, CL to Antofagasta

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