Find coaches from Santiago, CL to Antofagasta

Next departures

Next departures from Santiago to Antofagasta on 31 October
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Cikbus Elité
Terminal de Buses San Borja - San Francisco de Borja
Terminal AntofagastaCheapest
Cikbus Elité
Terminal de Buses San Borja - San Francisco de Borja
Terminal AntofagastaFastest
Cikbus Elité
Terminal de Buses San Borja - San Francisco de Borja
Terminal AntofagastaNo tags
Pluss Chile
San Borja
Terminal AntofagastaNo tags
Pullman San Andrés
San Borja
Terminal Carlos Oviedo CavadaNo tags

Last refresh of the prices: Today at 10:40 AM -03.

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Get from Santiago to Antofagasta

busbud logoThis route is served by bus only

The journey takes about 18 hours 40 minutes, and with fares starting at just US$27, it presents an excellent value for a comfortable ride.

40bus per day
18h 40mAverage duration
1095 kmDistance
27kgCO₂ emissions

Bus Santiago, CL to Antofagasta: Trip Overview

Average ticket priceUS$47
Average bus trip duration18h 40m
Number of daily buses40
Earliest bus departure06:15
Distance1094 km
Latest bus departure23:50

Santiago to Antofagasta Bus

With Busbud, comparing and booking tickets for a bus from Santiago to Antofagasta is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Santiago to Antofagasta from the most reliable bus companies operating this trip.

Discover how much the bus trip from Santiago to Antofagasta will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Santiago, CL - Antofagasta

  1. How much does a bus ticket from Santiago to Antofagasta cost?

    The bus ticket price from Santiago to Antofagasta starts at US$27. The best way to find cheap bus tickets from Santiago to Antofagasta is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

  2. How long is the bus ride from Santiago to Antofagasta?

    The average travel time between Santiago and Antofagasta is around 18h 40m, although the fastest bus will take about 17h 15m. This is the time it takes to travel the 1091 km that separates the two cities.

  3. How many daily bus connections are there between Santiago and Antofagasta?

    The number of buses from Santiago to Antofagasta can differ depending on the day of the week. On average, there are 40 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Santiago to Antofagasta by comparing and selecting the bus that fits your travel style and budget on Busbud.

  4. Which bus companies travel from Santiago to Antofagasta?

    When taking the bus from Santiago to Antofagasta, you can travel comfortably and safely with Pluss Chile, Cikbus Elité, Pullman San Andres.

  5. What are the departure and arrival stations when taking the bus from Santiago to Antofagasta?

    Buses travelling between Santiago and Antofagasta leave from San Borja or Terminal Sur and arrive at Terminal Antofagasta, Av. Pedro Aguirre Cerda, 253, Terminal Flota Barrios.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
28/10
US$35
29/10
US$35
Today
US$35
31/10
US$32
01/11
US$32
02/11
US$36
03/11
US$26
04/11
US$26
busbud logoThe cheapest trip from Santiago, CL to Antofagasta was searched and found on 03 Nov 2025 with a price of US$26

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santiago, CL to Antofagasta as early as possible.

You can expect to pay from US$26 to US$68 for a bus ticket from Santiago, CL to Antofagasta based on the last 2 days. You can expect to find the cheapest price for the trip at US$26, which is on 2025-11-03.

Usually Pullman San Andres, Pluss Chile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Santiago to Antofagasta.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Santiago to Antofagasta, get comfy and count the stars.

Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Santiago to Antofagasta will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Santiago to Antofagasta.

Did you know?

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Will you be returning to Santiago, CL by bus?

Bus from Antofagasta to Santiago, CL

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