Bus Tickets from Antofagasta to Santiago, CL

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TodayJun 3
from $36
TomorrowJun 4
from $34
ThuJun 5
from $26
FriJun 6
from $26
SatJun 7
from $26
SunJun 8
from $42
MonJun 9
from $26
TueJun 10

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: June 4 at
    Departure city: Antofagasta
    Departure location: Terminal Antofagasta
    Arrival time: June 5 at
    Destination city: Santiago
    Destination location: Terminal de Buses San Borja - San Francisco de Borja
    Operated by: Cikbus ElitéCikbus Elité
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: June 4 at
    Departure city: Antofagasta
    Departure location: Terminal Antofagasta
    Arrival time: June 4 at
    Destination city: Santiago
    Destination location: Terminal de Buses San Borja - San Francisco de Borja
    Operated by: Cikbus ElitéCikbus Elité
    Vehicle: BusDuration:
  • Departure time: June 4 at
    Departure city: Antofagasta
    Departure location: Terminal Antofagasta
    Arrival time: June 5 at
    Destination city: Santiago
    Destination location: Terminal de Buses San Borja - San Francisco de Borja
    Operated by: Cikbus ElitéCikbus Elité
    Vehicle: BusDuration:
  • Departure time: June 4 at
    Departure city: Antofagasta
    Departure location: Terminal Antofagasta
    Arrival time: June 4 at
    Destination city: Santiago
    Destination location: San Borja
    Operated by: Pluss ChilePluss Chile
    Vehicle: BusDuration:
  • Departure time: June 4 at
    Departure city: Antofagasta
    Departure location: 5791 Avenida Iquique
    Arrival time: June 4 at
    Destination city: Santiago
    Destination location: Terminal de Buses San Borja
    Operated by: AndimarAndimar
    Vehicle: BusDuration:

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Bus Antofagasta to Santiago: Trip Overview

Average ticket price$48
Average bus trip duration18h 15m
Number of daily buses38
Earliest bus departure12:15am
Distance679 miles (1094 km)
Latest bus departure11:59pm

Antofagasta to Santiago Bus

With Busbud, comparing and booking tickets for a bus from Antofagasta to Santiago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from Antofagasta to Santiago will be provided by the most trusted bus companies.

Discover how much the bus trip from Antofagasta to Santiago will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip Antofagasta - Santiago, CL

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06/01
$32
06/02
$38
Today
$32
06/04
$32
06/05
$24
06/06
$24
06/07
$24
06/08
$39
busbud logoThe cheapest trip from Antofagasta to Santiago was searched and found on Jun 6, 2025 with a price of $24

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Antofagasta to Santiago, as early as possible.

You can expect to pay from $24 to $65 for a bus ticket from Antofagasta to Santiago based on the last 2 days. You can expect to find the cheapest price for the trip at $24 which is on 2025-06-06.

Usually PlussChile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Antofagasta to Santiago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from Antofagasta to Santiago, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Antofagasta to Santiago will emit less CO2 than a car or an airplane.

Make a music playlist for your bus ride from Antofagasta to Santiago, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

Will you be returning to Antofagasta by bus?

Bus from Antofagasta to Santiago

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