What is the distance between Antofagasta and Santiago?

About 677 miles (1091 km) separate Antofagasta and Santiago.

What are the departure and arrival stations when taking the bus from Antofagasta to Santiago?

If you're headed to Santiago from Antofagasta, chances are that your bus will leave from Av. Pedro Aguirre Cerda, 253 and arrive at San Borja. These are the most popular departure and arrival locations on this route, but you can find others that could fit better into your travel plans.

What are the best sights and things to do in Santiago?

Once in Santiago, you can start exploring the city and discover its surroundings. The top sights and things to do are El Biógrafo, Museo de la Memoria y los Derechos Humanos, Parque Forestal, Casablanca Valley Wine Tasting and Cajon del Maipo.

Bus Antofagasta to Santiago from $26 | Refundable Tickets

Next bus departures

Next departures for Antofagasta to Santiago on November 19
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	1:35am	Terminal de Buses Cardenal Carlos Oviedo Cavada)	18h	7:35pm	Terminal San Borja	Cheapest
Bus	1:45am	Terminal Carlos Oviedo Cavada	17h	6:45pm	San Borja	Fastest
Bus	1:10am	Terminal Antofagasta	18h 40m	7:50pm	Terminal de Buses San Borja - San Francisco de Borja	No tags
Bus	12:55am	Terminal Antofagasta	17h 30m	6:25pm	San Borja	No tags
Bus	1:30am	Terminal Antofagasta	17h 35m	7:05pm	San Borja	No tags

Next departures for Antofagasta to Santiago on November 20
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	3:10am	Terminal Antofagasta	18h 50m	10:00pm	Terminal de Buses San Borja - San Francisco de Borja	Cheapest
Bus	1:45am	Terminal Carlos Oviedo Cavada	17h	6:45pm	San Borja	Fastest
Bus	8:30am	Terminal Antofagasta	21h	5:30am	Terminal de Buses San Borja - San Francisco de Borja	No tags
Bus	9:15pm	Terminal Antofagasta	17h 40m	2:55pm	San Borja	No tags
Bus	2:30pm	Terminal Carlos Oviedo Cavada	17h 30m	8:00am	San Borja	No tags

Next departures for Antofagasta to Santiago on November 21
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	10:15pm	Terminal Antofagasta	18h 15m	4:30pm	Terminal de Buses San Borja - San Francisco de Borja	Cheapest
Bus	11:45pm	Terminal Antofagasta	17h	4:45pm	Terminal de Buses San Borja - San Francisco de Borja	Fastest
Bus	8:30am	Terminal Antofagasta	21h	5:30am	Terminal de Buses San Borja - San Francisco de Borja	No tags
Bus	12:15am	Terminal Antofagasta	18h 20m	6:35pm	San Borja	No tags
Bus	1:45am	Terminal Carlos Oviedo Cavada	17h	6:45pm	San Borja	No tags

Next departures for Antofagasta to Santiago on November 22
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	1:35am	Terminal de Buses Cardenal Carlos Oviedo Cavada)	18h	7:35pm	Terminal San Borja	Cheapest
Bus	1:45am	Terminal Carlos Oviedo Cavada	17h	6:45pm	San Borja	Fastest
Bus	11:00am	Terminal Antofagasta	18h 20m	5:20am	San Borja	No tags
Bus	2:30pm	Terminal Carlos Oviedo Cavada	17h 30m	8:00am	San Borja	No tags
Bus	3:35am	Terminal de Buses Cardenal Carlos Oviedo Cavada)	18h	9:35pm	Terminal San Borja	No tags

Next departures for Antofagasta to Santiago on November 23
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	1:35am	Terminal de Buses Cardenal Carlos Oviedo Cavada)	18h	7:35pm	Terminal San Borja	Cheapest
	Bus	1:45am	Terminal Carlos Oviedo Cavada	17h	6:45pm	San Borja	Fastest
	Bus	2:30pm	Terminal Carlos Oviedo Cavada	17h 30m	8:00am	San Borja	No tags
	Bus	3:35am	Terminal de Buses Cardenal Carlos Oviedo Cavada)	18h	9:35pm	Terminal San Borja	No tags
Andimar + Flixbus Chile	Bus	1:35am	Terminal de Buses Cardenal Carlos Oviedo Cavada)	19h 35m	9:10pm	Santiago (Los Libertadores)	No tags

Next departures for Antofagasta to Santiago on November 24
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	3:10am	Terminal Antofagasta	18h 50m	10:00pm	Terminal de Buses San Borja - San Francisco de Borja	Cheapest
Bus	1:45am	Terminal Carlos Oviedo Cavada	17h	6:45pm	San Borja	Fastest
Bus	3:10am	Terminal Antofagasta	18h 50m	10:00pm	Terminal de Buses San Borja - San Francisco de Borja	No tags
Bus	10:30am	Terminal Antofagasta	18h 20m	4:50am	San Borja	No tags
Bus	2:30pm	Terminal Carlos Oviedo Cavada	17h 30m	8:00am	San Borja	No tags

Next departures for Antofagasta to Santiago on November 25
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	8:30am	Terminal Antofagasta	21h	5:30am	Terminal de Buses San Borja - San Francisco de Borja	Cheapest
Bus	1:45am	Terminal Carlos Oviedo Cavada	17h	6:45pm	San Borja	Fastest
Bus	8:30am	Terminal Antofagasta	21h	5:30am	Terminal de Buses San Borja - San Francisco de Borja	No tags
Bus	8:00pm	Terminal Antofagasta	17h 30m	1:30pm	San Borja	No tags
Bus	12:00pm	Terminal Antofagasta	18h 15m	6:15am	San Borja	No tags

Last refresh of the prices: Today at 9:53 PM -03.

Get from Antofagasta to Santiago

This route is served by bus only

The journey takes about 18 hours 15 minutes and with fares starting at just $27, it presents an excellent value for a comfortable ride.

39bus per day

18h 15mAverage Duration

679 milesDistance

27kgCO₂ emissions

Compare bus companies

Pluss Chile

4/579 reviews

Staff4.5

Timeliness3.9

Cleanliness4.6

Wifi1.4

Pullman San Andres

3.5/513 reviews

Timeliness0

Cikbus Elité

3.5/5125 reviews

Staff4.5

Timeliness3.1

Cleanliness4.1

Wifi1.4

Buses Andimar

4/554 reviews

Staff4.4

Timeliness4.6

Cleanliness4.6

Wifi1.2

Clikbus

4.5/53 reviews

Staff5

Timeliness5

Cleanliness3.4

Wifi0

CL bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Where are the popular stops in Antofagasta and Santiago?

Stops in Antofagasta

A - Av. Pedro Aguirre Cerda, 253

B - Terminal Antofagasta

C - Terminal Flota Barrios

D - Terminal Pullman Bus

E - Terminal Buses Camus

F - Terminal Tur Bus

Stops in Santiago

A - San Borja

B - Terminal Sur

C - Terminal Los Héroes

D - Terminal ETM

E - Pajaritos

F - Santiago

Frequently asked questions about traveling from Antofagasta to Santiago, CL by bus

What is the distance between Antofagasta and Santiago?
What are the departure and arrival stations when taking the bus from Antofagasta to Santiago?
What are the best sights and things to do in Santiago?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/15

$33

11/16

$33

Today

$36

11/18

$36

11/19

$33

11/20

$26

11/21

$26

11/22

$33

The cheapest trip from Antofagasta to Santiago, CL was searched and found on Nov 20, 2025 with a price of $26

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Antofagasta to Santiago, CL, as early as possible.

You can expect to pay from $26 to $66 for a bus ticket from Antofagasta to Santiago, CL based on the last 2 days. You can expect to find the cheapest price for the trip at $26 which is on 2025-11-20.

Usually Pluss Chile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.