Find coaches from Greenville, SC to Knoxville, TN

Next departures

Next departures from Greenville to Knoxville on 31 October
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc.
1116 Woodruff Rd
Knoxville Bus StationCheapestFastest

Last refresh of the prices: Last Wednesday at 2:43 AM EDT.

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Get from Greenville to Knoxville

busbud logoThis route is served by bus only

The journey takes about 7 hours 5 minutes, and with fares starting at just US$66, it presents an excellent value for a comfortable ride.

1bus per day
7h 5mAverage duration
193 kmDistance
5kgCO₂ emissions

Bus Greenville, SC to Knoxville, TN: Trip Overview

Average ticket priceUS$89
Average bus trip duration7h 5m
Number of daily buses1
Earliest bus departure14:45
Distance193 km

Greenville to Knoxville Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Greenville to Knoxville.

Bus service from Greenville to Knoxville will be provided by the most trusted bus companies.

Discover how much the bus trip from Greenville to Knoxville will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Greenville, SC - Knoxville, TN

  1. How much does a bus ticket from Greenville to Knoxville cost?

    The bus ticket price from Greenville to Knoxville starts at US$66. The best way to find cheap bus tickets from Greenville to Knoxville is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

  2. How long is the bus ride from Greenville to Knoxville?

    The average travel time between Greenville and Knoxville is around 7h 5m, although the fastest bus will take about 7h 5m. This is the time it takes to travel the 186 km that separates the two cities.

  3. How many daily bus connections are there between Greenville and Knoxville?

    The number of buses from Greenville to Knoxville can differ depending on the day of the week. On average, there are 1 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Greenville to Knoxville by comparing and selecting the bus that fits your travel style and budget on Busbud.

  4. Which bus companies travel from Greenville to Knoxville?

    When taking the bus from Greenville to Knoxville, you can travel comfortably and safely with Greyhound, FlixBus.

  5. What are the departure and arrival stations when taking the bus from Greenville to Knoxville?

    Buses travelling between Greenville and Knoxville leave from Guadalajara Supermarket Bus Stop or Greenville Bus Station and arrive at 100 Kirkwood St.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
29/10
No data
30/10
US$72
Today
US$62
01/11
US$61
02/11
No data
03/11
No data
04/11
US$59
05/11
No data
busbud logoThe cheapest trip from Greenville, SC to Knoxville, TN was searched and found on 04 Nov 2025 with a price of US$59

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Knoxville, TN as early as possible.

You can expect to pay from US$59 to US$72 for a bus ticket from Greenville, SC to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at US$59, which is on 2025-11-04.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Greenville to Knoxville but it'll also be endearing to native speakers who will surely appreciate your effort.

Much more than a mere vehicle taking you from Greenville to Knoxville, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Greenville to Knoxville will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

Make a music playlist for your bus ride from Greenville to Knoxville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Will you be returning to Greenville, SC by bus?

Bus from Knoxville, TN to Greenville, SC

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