Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Charlottesville Union Station | Gateway Station | Cheapest | ||||
 | Bus | Charlottesville Union Station | Gateway Station | Fastest |
Last refresh of the prices: Today at 2:58 PM EST.
Compare 2 ways to go from Charlottesville to St. Louis
Among the sustainable travel choices, the bus stands out as the good way to reach St. Louis. The journey takes about 1 day, 6 hours 40 minutes and with fares starting at just $119, it presents an excellent value for a comfortable ride.
Where are the popular stops in Charlottesville and St. Louis?
Stops in Charlottesville
- A
Campbells Travel Bus Stop
310 W Main St, Charlottesville, VA 22903
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Charlottesville to St. Louis by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Charlottesville to St. Louis?
The cheapest bus tickets from Charlottesville to St. Louis start from $119. The average price for this route is around $153. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Charlottesville to St. Louis?
The average bus trip duration from Charlottesville to St. Louis is 1d 6h, covering a distance of 635 miles (1024 km). The quickest bus can get you there in 1d and is operated by Greyhound.
Which bus companies service the Charlottesville to St. Louis route?
Several major train operators operate on this route with 1 trains available per day.
What is the earliest and latest departure time for the bus from Charlottesville to St. Louis?
The earliest bus departs from Charlottesville to St. Louis at 7:15am. And the latest bus departs at 9:40am.
What are the CO₂ emissions for the bus trip from Charlottesville to St. Louis?
A bus trip from Charlottesville to St. Louis generates an estimated 26 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Charlottesville to St. Louis was searched and found on Dec 10, 2025 with a price of $121To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Charlottesville to St. Louis, as early as possible.
You can expect to pay from $121 to $163 for a bus ticket from Charlottesville to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $121 which is on 2025-12-10.
What's the cheapest way to go from Charlottesville to St. Louis?
The bus is the cheapest travel choice for this destinationTop traveled bus routes
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Popular bus departures from Charlottesville
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