Next departures for Chicago to St. Louis on November 24
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Downtown Greyhound Station
Gateway Station
Cheapest
Bus
Chicago 95Th & Dan Ryan
Gateway Station
Fastest
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
537-517 W. Jackson Blvd
Gateway Station
No tags
Next departures for Chicago to St. Louis on November 25
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Chicago 95Th & Dan Ryan
Gateway Station
Cheapest
Bus
Chicago 95Th & Dan Ryan
Gateway Station
Fastest
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Gateway Station
No tags
Next departures for Chicago to St. Louis on November 26
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Downtown Greyhound Station
Gateway Station
Cheapest
Bus
Chicago 95Th & Dan Ryan
Gateway Station
Fastest
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Gateway Station
No tags
Next departures for Chicago to St. Louis on November 27
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Downtown Greyhound Station
Gateway Station
Cheapest
Bus
Chicago 95Th & Dan Ryan
Gateway Station
Fastest
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Gateway Station
No tags
Next departures for Chicago to St. Louis on November 28
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Downtown Greyhound Station
Gateway Station
Cheapest
Bus
Chicago 95Th & Dan Ryan
Gateway Station
Fastest
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Gateway Station
No tags
Next departures for Chicago to St. Louis on November 29
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Downtown Greyhound Station
Gateway Station
Cheapest
Bus
Chicago 95Th & Dan Ryan
Gateway Station
Fastest
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Gateway Station
No tags
Next departures for Chicago to St. Louis on November 30
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Chicago 95Th & Dan Ryan
Gateway Station
Cheapest
Bus
Chicago 95Th & Dan Ryan
Gateway Station
Fastest
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Gateway Station
No tags
Next departures for Chicago to St. Louis on December 1
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Downtown Greyhound Station
Gateway Station
Cheapest
Bus
Chicago 95Th & Dan Ryan
Gateway Station
Fastest
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Gateway Station
No tags
Last refresh of the prices: Yesterday at 11:07 PM CST.
Compare 2 ways to go from Chicago to St. Louis
We recommend taking the train
Among the sustainable travel choices, the train stands out as the good way to reach St. Louis. The journey takes about 5 hours 1 minute and with fares starting at just $30, it presents an excellent value for a comfortable ride.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Chicago St. Louis recent customer reviews
It was an awful experience never I will book a flixbus. Bus did not come on time it was more than 6 hours late and no one can ready for the replay. Zero services.
1 out of 5 stars
Harshil Jagdish U.
Workers at the Greyhound station of Chicago and St. Louis were very helpful. Not the friendliest, but helpful indeed. The bus itself was over 2hrs late with no explanation and we were not told how long of a delay it would be upon initial announcement.
2 out of 5 stars
Amber H.
Our bus was supposed to leave Chicago at 1:30 in the morning, we did not leave until 5:30. It was very late and a huge inconvenience. The station was also very dirty, so there was not clean places to sit and wait.
Based on 20 reviews, the company was rated 4.2 stars on Busbud. Travelers were especially satisfied with the staff and the timeliness but often complained with the ticket access. Burlington Trailways ticket prices on this trip start at $182
Customers have shared positive experiences regarding their recent trips. They appreciated the quiet and smooth rides, comfortable seating with ample space to relax or sleep, and efficient senior customer assistance. Additionally, travelers noted that the train was very clean and enjoyed improved food quality compared to previous journeys.
Amtrak Chicago St. Louis recent customer reviews
My trip experience was very quiet and smooth. I was in comfort and had plenty of space where I could relax and get some sleep. My trip was 4 1/2 hours.
4 out of 5 stars
Rosemarie H.
Everything was fine, senior customer assistance, smooth ride,nice seating all good
5 out of 5 stars
Samuel S.
The trip was the fastest available option. The train was very clean. I like how they announced for people to respect others and keep noise down by using headphones etc. I believe there was Wi-Fi available, I didn’t need though.
It was a great Amtrak experience I had compared to my past Amtrak travels, I remember from more than 2-3 years back. The food was also better than I remembered.
Frequently asked questions about traveling from Chicago to St. Louis by bus
How much does a bus ticket from Chicago to St. Louis cost?
The bus ticket price from Chicago to St. Louis starts at $38. The best way to find cheap bus tickets from Chicago to St. Louis is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the bus ride from Chicago to St. Louis?
The average travel time between Chicago and St. Louis is around 7h 55m, although the fastest bus will take about 4h 45m. This is the time it takes to travel the 260 miles that separates the two cities.
How many daily bus connections are there between Chicago and St. Louis?
The number of buses from Chicago to St. Louis can differ depending on the day of the week. On average, there are 11 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Chicago to St. Louis by comparing and selecting the bus that fits you travel style and budget on Busbud.
Which bus companies travel from Chicago to St. Louis?
When taking the bus from Chicago to St. Louis, you can travel comfortably and safely with FlixBus, Greyhound, Burlington Trailways.
What are the departure and arrival stations when taking the bus from Chicago to St. Louis?
Buses traveling between Chicago and St. Louis leave from Downtown Greyhound Station or Chicago O'Hare International Airport and arrive at Gateway Station.
What are the best sights and things to do in St. Louis?
Once in St. Louis, you can start exploring the city and discover its surroundings. The top sights and things to do are Anheuser-Busch Brewery, Forest Park, Old St. Louis County Courthouse, Saint Louis Zoo, Gateway Arch.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/22
$83
11/23
$75
Today
$62
11/25
$61
11/26
$71
11/27
$49
11/28
$49
11/29
$51
The cheapest trip from Chicago to St. Louis was searched and found on Nov 27, 2025 with a price of $49
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to St. Louis, as early as possible.
You can expect to pay from $49 to $159 for a bus ticket from Chicago to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $49 which is on 2025-11-27.
Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
The cheapest trip from Chicago to St. Louis was searched and found on Nov 27, 2025 with a price of $49
