Bus Tickets from Durham, NC to Florence, SC

Find affordable bus tickets from Durham, NC to Florence, SC with flexible options. Book your trip now

Join 75M+ travelers booking 2M+ routes across 85+ countries.
Enjoy our 24/7 customer service to assist you at every step.
Cancel anytime and receive a 100% refund, no reason needed.
TodayMay 10
TomorrowMay 11
MonMay 12
TueMay 13
WedMay 14
ThuMay 15
FriMay 16
from $51
SatMay 17

Cheap buses leaving Friday

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: May 16 at
    Departure city: Durham
    Departure location: Durham Greyhound Bus Station
    Arrival time: May 17 at
    Destination city: Florence
    Destination location: Florence, SC
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: May 16 at
    Departure city: Durham
    Departure location: BP Gas Station
    Arrival time: May 16 at
    Destination city: Florence
    Destination location: 2301 W Lucas St.
    Operated by: Wanda CoachWanda Coach
    Vehicle: BusDuration:
  • Departure time: May 16 at
    Departure city: Durham
    Departure location: BP Gas Station
    Arrival time: May 16 at
    Destination city: Florence
    Destination location: 2301 W Lucas St.
    Operated by: Wanda CoachWanda Coach
    Vehicle: BusDuration:

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to go from Durham to Florence.

Bus
Average Price$40 - $68Average Duration3h 40m
5kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average Price$47 - $69Average Duration8h 25m
20kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Durham to Florence

Among the sustainable travel choices, the bus stands out as the good way to reach Florence. The journey takes about 3 hours 40 minutes and with fares starting at just $40, it presents an excellent value for a comfortable ride.

1bus per day
3h 40mAverage Duration
$40Cheapest ticket
5kgCO₂ emissions

Bus Durham to Florence: Trip Overview

Average ticket price$67
Average bus trip duration3h 40m
Number of daily buses1
Earliest bus departure4:20am
Distance134 miles (215 km)
Latest bus departure9:15pm

Durham to Florence Bus

Busbud helps you find a bus from Durham to Florence. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from Durham to Florence from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to Florence from Durham, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip Durham - Florence

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
05/08
$40
05/09
No data
Today
No data
05/11
No data
05/12
No data
05/13
No data
05/14
No data
05/15
No data
busbud logoThe cheapest trip from Durham to Florence was searched and found on May 8, 2025 with a price of $40

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Durham to Florence, as early as possible.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Durham and Florence!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Durham to Florence, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Durham to Florence.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Durham to Florence.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Will you be returning to Durham by bus?

Bus from Durham to Florence

You can also go to Florence by train

Train from Durham to Florence

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With several language and currency options available, Busbud seeks to cater to international bus travelers no matter where they are in the world. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

‌

Popular Buses Connecting Durham

Buses Leaving from Durham

Buses Going to Durham

Popular Buses Connecting Florence

Buses Leaving from Florence

Buses Going to Florence