Bus Tickets from Durham (NC), US to Harrisburg

Find affordable bus tickets from Durham (NC), US to Harrisburg with flexible options. Book your trip now

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TodayJun 7
TomorrowJun 8
from $102
MonJun 9
from $81
TueJun 10
from $74
WedJun 11
from $79
ThuJun 12
from $76
FriJun 13
from $92
SatJun 14
from $78

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: June 8 at
    Departure city: Durham
    Departure location: Durham Greyhound Bus Station
    Arrival time: June 9 at
    Destination city: Harrisburg
    Destination location: Harrisburg
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: June 8 at
    Departure city: Durham
    Departure location: Durham Greyhound Bus Station
    Arrival time: June 8 at
    Destination city: Harrisburg
    Destination location: Harrisburg Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: June 8 at
    Departure city: Durham
    Departure location: Durham Greyhound Bus Station
    Arrival time: June 8 at
    Destination city: Harrisburg
    Destination location: Harrisburg Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: June 8 at
    Departure city: Durham
    Departure location: Durham Greyhound Bus Station
    Arrival time: June 8 at
    Destination city: Harrisburg
    Destination location: Harrisburg Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: June 8 at
    Departure city: Durham
    Departure location: Durham Greyhound Bus Station
    Arrival time: June 9 at
    Destination city: Harrisburg
    Destination location: Harrisburg
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:

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Compare 2 ways to go from Durham to Harrisburg.

Average Price$68 - $158Average Duration17h 30m
13kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Average Price$133 - $133Average Duration13h 56m
46kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the train from Durham to Harrisburg

Among the sustainable travel choices, the train stands out as the good way to reach Harrisburg. The journey takes about 13 hours 56 minutes and with fares starting at just $133, it presents an excellent value for a comfortable ride.

1train per day
13h 56mAverage Duration
$133Cheapest ticket
46kgCO₂ emissions

Bus Durham to Harrisburg: Trip Overview

Average ticket price$86
Average bus trip duration17h 30m
Number of daily buses5
Earliest bus departure2:45am
Distance314 miles (506 km)
Latest bus departure9:55pm

Durham to Harrisburg Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Durham to Harrisburg.

We make sure you can find a bus service from Durham to Harrisburg from the most reliable bus companies operating this trip.

Discover how much the bus trip from Durham to Harrisburg will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip Durham (NC), US - Harrisburg

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06/05
$74
06/06
No data
Today
$81
06/08
$132
06/09
$74
06/10
$67
06/11
$72
06/12
$68
busbud logoThe cheapest trip from Durham to Harrisburg was searched and found on Jun 10, 2025 with a price of $67

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Durham to Harrisburg, as early as possible.

You can expect to pay from $67 to $159 for a bus ticket from Durham to Harrisburg based on the last 2 days. You can expect to find the cheapest price for the trip at $67 which is on 2025-06-10.

Usually Greyhound Lines, Inc. will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Durham to Harrisburg but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Durham to Harrisburg, get comfy and count the stars.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Durham to Harrisburg will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Durham to Harrisburg.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

What's the cheapest way to go from Durham to Harrisburg?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Durham by bus?

Bus from Durham to Harrisburg

You can also go to Harrisburg by train

Train from Durham to Harrisburg

Why choose Busbud?

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Popular Buses Connecting Durham

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Popular Buses Connecting Harrisburg

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