Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Durham Greyhound Bus Station | Harrisburg Bus Station | Cheapest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Durham Greyhound Bus Station | Harrisburg Bus Station | Fastest | ||||
 | Bus | Durham Greyhound Bus Station | Harrisburg Bus Station | No tags |
Last refresh of the prices: Yesterday at 9:45 AM EST.
Compare 2 ways to go from Durham to Harrisburg
Among the sustainable travel choices, the Train stands out as the good way to reach Harrisburg. The journey takes about 14 hours 29 minutes and with fares starting at just $125, it presents an excellent value for a comfortable ride.
Where are the popular stops in Durham and Harrisburg?
Stops in Durham
- A515 W Pettigrew St , Durham, NC 27703
- B
Compare Foods Durham
2000-2004 NC-55, Durham, NC 27704, USA - C
Durham Compare Foods Durham
2000 Avondale Dr, Durham, NC 27704, USA - D
Durham, NC
E Main St at Roxboro St (WB), Durham, NC 27701, USA
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Frequently asked questions about traveling from Durham, NC, US to Harrisburg by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Durham to Harrisburg?
The cheapest bus tickets from Durham to Harrisburg start from $71. The average price for this route is around $134. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Durham to Harrisburg?
The average bus trip duration from Durham to Harrisburg is 16h 40m, covering a distance of 314 miles (507 km). The quickest bus can get you there in 17h 15m and is operated by Greyhound.
Which bus companies service the Durham to Harrisburg route?
What is the earliest and latest departure time for the bus from Durham to Harrisburg?
The earliest bus departs from Durham to Harrisburg at 2:40am. And the latest bus departs at 10:05pm.
What are the CO₂ emissions for the bus trip from Durham to Harrisburg?
A bus trip from Durham to Harrisburg generates an estimated 13 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Durham to Harrisburg?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87500 reviews.
Which bus company has the best Wi-Fi from Durham to Harrisburg?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Durham to Harrisburg?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Durham to Harrisburg?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Durham, NC, US to Harrisburg was searched and found on Jan 20, 2026 with a price of $94To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Durham, NC, US to Harrisburg, as early as possible.
You can expect to pay from $94 to $94 for a bus ticket from Durham, NC, US to Harrisburg based on the last 2 days. You can expect to find the cheapest price for the trip at $94 which is on 2026-01-20.
What's the cheapest way to go from Durham, NC, US to Harrisburg?
The Bus is the cheapest travel choice for this destination
