Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound | Bus | Jackson (Union Station) | Florence, SC | No tags | ||||
FlixBus + Greyhound | Bus | Jackson (Union Station) | Florence, SC | No tags | ||||
FlixBus + Greyhound | Bus | Jackson (Union Station) | Florence, SC | No tags | ||||
Greyhound + FlixBus | Bus | Jackson (Union Station) | Florence, SC | No tags | ||||
 | Bus | Jackson (Union Station) | Bus station | No tags |
Compare 2 ways to go from Jackson to Florence
Among the sustainable travel choices, the bus stands out as the good way to reach Florence. The journey takes about 19 hours and with fares starting at just $140, it presents an excellent value for a comfortable ride.
Where are the popular stops in Jackson and Florence?
Stops in Jackson
- A
Jackson Bus Station
300 W Capitol St, Jackson, MS 39201, USA - B
Love's Travel Stop - Jackson
730 US-80, Flowood, MS 39232, USA
Stops in Florence
- A619 S Irby St, Florence, SC 29501, USA
- B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Jackson, MS, US to Florence, SC, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Jackson to Florence?
The cheapest bus tickets from Jackson to Florence start from $140. The average price for this route is around $149. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Jackson to Florence?
The average bus trip duration from Jackson to Florence is 19h, covering a distance of 615 miles (992 km). The quickest bus can get you there in 18h 50m and is operated by Greyhound.
Which bus companies service the Jackson to Florence route?
Several major train operators operate on this route with 2 trains available per day.
What is the earliest and latest departure time for the bus from Jackson to Florence?
The earliest bus departs from Jackson to Florence at 5:30pm. And the latest bus departs at 5:30pm.
What are the CO₂ emissions for the bus trip from Jackson to Florence?
A bus trip from Jackson to Florence generates an estimated 25 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Jackson, MS, US to Florence, SC, US was searched and found on Dec 16, 2025 with a price of $132To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Jackson, MS, US to Florence, SC, US, as early as possible.
What's the cheapest way to go from Jackson, MS, US to Florence, SC, US?
The bus is the cheapest travel choice for this destination
