Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Goerke's Corners Park & Ride (Brookfield) | Florence, SC | Cheapest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Milwaukee Mitchell MKE Airport | Bus station | Fastest | ||||
 | Bus | Milwaukee Bus Station, St. Paul & N6th road. | Bus station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Milwaukee Bus Station, St. Paul & N6th road. | Bus station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Milwaukee Bus Station, St. Paul & N6th road. | Bus station | No tags |
Last refresh of the prices: Last Saturday at 7:45 PM CST.
Compare 2 ways to go from Milwaukee to Florence
Among the sustainable travel choices, the bus stands out as the good way to reach Florence. The journey takes about 1 day, 8 hours 15 minutes and with fares starting at just $142, it presents an excellent value for a comfortable ride.
Where are the popular stops in Milwaukee and Florence?
Stops in Milwaukee
- B433 W St Paul Ave, Milwaukee, WI 53203, USA
- C
S Cesar Chavez
1016 S Cesar E Chavez Dr, Milwaukee, WI 53204, USA
Stops in Florence
- A619 S Irby St, Florence, SC 29501, USA
- B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Milwaukee to Florence, SC, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Milwaukee to Florence?
The cheapest bus tickets from Milwaukee to Florence start from $142. The average price for this route is around $170. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Milwaukee to Florence?
The average bus trip duration from Milwaukee to Florence is 1d 8h, covering a distance of 746 miles (1202 km). The quickest bus can get you there in 1d 7h and is operated by Greyhound.
Which bus companies service the Milwaukee to Florence route?
Several major train operators operate on this route with 13 trains available per day.
What is the earliest and latest departure time for the bus from Milwaukee to Florence?
The earliest bus departs from Milwaukee to Florence at 3:20am. And the latest bus departs at 7:35pm.
What are the CO₂ emissions for the bus trip from Milwaukee to Florence?
A bus trip from Milwaukee to Florence generates an estimated 30 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Milwaukee to Florence, SC, US was searched and found on Dec 20, 2025 with a price of $195To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Milwaukee to Florence, SC, US, as early as possible.
You can expect to pay from $195 to $195 for a bus ticket from Milwaukee to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $195 which is on 2025-12-20.
What's the cheapest way to go from Milwaukee to Florence, SC, US?
The bus is the cheapest travel choice for this destination
