Bus Tickets from Santiago del Estero to Santa Fe

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WedMay 21
from $35
ThuMay 22
from $35
FriMay 23
from $49
SatMay 24
SunMay 25
MonMay 26
TueMay 27
WedMay 28

Cheap buses leaving Thursday

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: May 22 at
    Departure city: Santiago del Estero
    Departure location: Terminal de Ómnibus de Santiago del Estero
    Arrival time: May 23 at
    Destination city: Santa Fe
    Destination location: Estación Terminal de Ómnibius, Santa Fe
    Operated by: Flecha BusFlecha Bus
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: May 22 at
    Departure city: Santiago del Estero
    Departure location: Terminal de Ómnibus de Santiago del Estero
    Arrival time: May 23 at
    Destination city: Santa Fe
    Destination location: Estación Terminal de Ómnibius, Santa Fe
    Operated by: El PracticoEl Practico
    Vehicle: BusDuration:
  • Departure time: May 22 at
    Departure city: Santiago del Estero
    Departure location: Terminal de Ómnibus de Santiago del Estero
    Arrival time: May 23 at
    Destination city: Santa Fe
    Destination location: Estación Terminal de Ómnibius, Santa Fe
    Operated by: El PracticoEl Practico
    Vehicle: BusDuration:
  • Departure time: May 22 at
    Departure city: Santiago del Estero
    Departure location: Terminal de Ómnibus de Santiago del Estero
    Arrival time: May 23 at
    Destination city: Santa Fe
    Destination location: Estación Terminal de Ómnibius, Santa Fe
    Operated by: Flecha BusFlecha Bus
    Vehicle: BusDuration:
  • Departure time: May 22 at
    Departure city: Santiago del Estero
    Departure location: Terminal de Ómnibus de Santiago del Estero
    Arrival time: May 23 at
    Destination city: Santa Fe
    Destination location: Estación Terminal de Ómnibius, Santa Fe
    Operated by: El PracticoEl Practico
    Vehicle: BusDuration:

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Bus Santiago del Estero to Santa Fe: Trip Overview

Average ticket price$53
Average bus trip duration9h 35m
Number of daily buses1
Earliest bus departure9:10pm
Distance341 miles (550 km)
Latest bus departure10:00pm

Santiago del Estero to Santa Fe Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Santiago del Estero to Santa Fe.

Bus service from Santiago del Estero to Santa Fe will be provided by the most trusted bus companies.

Whether it is cheap bus tickets or more luxurious buses going to Santa Fe from Santiago del Estero, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip Santiago del Estero - Santa Fe

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
05/17
$50
05/18
$50
Today
$34
05/20
$52
05/21
$35
05/22
$35
05/23
$49
05/24
$48
busbud logoThe cheapest trip from Santiago del Estero to Santa Fe was searched and found on May 19, 2025 with a price of $34

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santiago del Estero to Santa Fe, as early as possible.

You can expect to pay from $34 to $58 for a bus ticket from Santiago del Estero to Santa Fe based on the last 2 days. You can expect to find the cheapest price for the trip at $35 which is on 2025-05-21.

Usually El Practico, Flechabus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Santiago del Estero to Santa Fe but it'll also be endearing to native speakers who will surely appreciate your effort.

Much more than a mere vehicle taking you from Santiago del Estero to Santa Fe, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Santiago del Estero to Santa Fe.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Santiago del Estero to Santa Fe.

Did you know?

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

Will you be returning to Santiago del Estero by bus?

Bus from Santiago del Estero to Santa Fe

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