Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Gateway Station | Jacksonville Bus Station | CheapestFastest |
Last refresh of the prices: Yesterday at 6:14 PM CDT.
Compare 2 ways to go from St. Louis to Jacksonville
Among the sustainable travel choices, the Bus stands out as a good way to reach Jacksonville. The journey takes about 22 hours 20 minutes and with fares starting at just $110, it presents an excellent value for a comfortable ride.
Where are the popular stops in St. Louis and Jacksonville?
Stops in Jacksonville
- A
Jacksonville Amtrak Station
3570 Clifford Ln, Jacksonville, FL 32209, USA - B
W Forsyth St
1111 W Forsyth St, Jacksonville, FL 32204, USA - C
Kings Avenue Station
1003 Kings Avenue, Jacksonville, FL 32207 - D
JRTC Greyhound Bus Station
111 W. Forsyth St, Jacksonville, FL 32202, USA
Compare bus companies
Frequently asked questions about traveling from St. Louis to Jacksonville, FL by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from St. Louis to Jacksonville?
The cheapest bus tickets from St. Louis to Jacksonville start from $110. The average price for this route is around $182. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from St. Louis to Jacksonville?
The average bus trip duration from St. Louis to Jacksonville is 22h 20m, covering a distance of 749 miles (1208 km). The quickest bus can get you there in 22h 20m and is operated by FlixBus.
Which bus companies service the St. Louis to Jacksonville route?
What is the earliest and latest departure time for the bus from St. Louis to Jacksonville?
The earliest bus departs from St. Louis to Jacksonville at 2:00am. And the latest bus departs at 11:45pm.
What are the CO₂ emissions for the bus trip from St. Louis to Jacksonville?
A bus trip from St. Louis to Jacksonville generates an estimated 30.199450000000002 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from St. Louis to Jacksonville?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 12791 reviews.
Which bus company has the best Wi-Fi from St. Louis to Jacksonville?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from St. Louis to Jacksonville?
According to Busbud traveler reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from St. Louis to Jacksonville?
According to Busbud traveler reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from St. Louis to Jacksonville, FL was searched and found on Jun 15, 2026 with a price of $112To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Jacksonville, FL, as early as possible.
You can expect to pay from $112 to $178 for a bus ticket from St. Louis to Jacksonville, FL based on the last 2 days. You can expect to find the cheapest price for the trip at $112 which is on 2026-06-15.
What's the cheapest way to go from St. Louis to Jacksonville, FL?
The Bus is the cheapest travel choice for this destination
