What is the distance between St. Louis and Louisville?

The distance separating St. Louis and Louisville is 242 miles (390 km).

What are the departure and arrival stations when taking the bus from St. Louis to Louisville?

Buses going from St. Louis to Louisville start their journey at Gateway Station and reach their destination at Louisville Greyhound Bus Station.

Bus St. Louis to Louisville from $63 | Refundable Tickets

Next bus departures

Next departures for St. Louis to Louisville on November 13
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
FlixBus + Greyhound Lines, Inc.	Bus	11:30pm	Gateway Station	12h 55m	1:25pm	Louisville, KY	CheapestFastest

Last refresh of the prices: Yesterday at 6:51 PM CST.

Get from St. Louis to Louisville

This route is served by bus only

The journey takes about 10 hours 25 minutes and with fares starting at just $41, it presents an excellent value for a comfortable ride.

4bus per day

10h 25mAverage Duration

241 milesDistance

10kgCO₂ emissions

Compare bus companies

Greyhound

3.5/587,370 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

Greyhound St. Louis Louisville recent customer reviews

The bus driver was very hateful and had absolutely no patience with all boarders. Her lack of warmth and listening skills when speaking resulted in riders being confused and frustrated. I am handicap and have difficulty with my legs but she moved me from one handicap seat to another across the bus ... nonhandicap men ending up sitting in my seat I was moved from. I ended up with a nonhandicap very very VERY large person next to me and I couldn't move my legs the entire trip. I was smashed in and with ms I simply can't be put into one position and expected to not move for hours. Her lack of noticing and caring was zero. The bus smelled horrible of sewage and rotten eggs, I assume it was coming from the mobile bathroom.

Faiza O.

April 28, 2018

FlixBus

3.5/511,296 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Where are the popular stops in St. Louis and Louisville?

Stops in St. Louis

A - Gateway Station

Stops in Louisville

A - Louisville Greyhound Bus Station

Frequently asked questions about traveling from St. Louis to Louisville by bus

What is the distance between St. Louis and Louisville?
What are the departure and arrival stations when taking the bus from St. Louis to Louisville?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/11

$78

11/12

$78

Today

$78

11/14

$63

11/15

No data

11/16

No data

11/17

No data

11/18

No data

The cheapest trip from St. Louis to Louisville was searched and found on Nov 14, 2025 with a price of $63

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Louisville, as early as possible.

You can expect to pay from $63 to $126 for a bus ticket from St. Louis to Louisville based on the last 2 days. You can expect to find the cheapest price for the trip at $63 which is on 2025-11-14.