Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Gateway Station | Winston Salem Greyhound Bus Station | Cheapest | ||||
| Bus | Gateway Station | Winston Salem Greyhound Bus Station | Fastest |
Last refresh of the prices: Last Sunday at 2:36 AM CST.
Get from St. Louis to Winston-Salem
The journey takes about 1 day, 4 hours and with fares starting at just $114, it presents an excellent value for a comfortable ride.
Where are the popular stops in St. Louis and Winston-Salem?
Stops in Winston-Salem
- A
Winston Salem Greyhound Bus Station
100 W 5th St, Winston Salem, NC 27101 - B
E Sprague St
841 E Sprague St, Winston-Salem, NC 27107, USA - C
Winston-Salem Bus Stop
2500 Old Lexington Rd, Winston-Salem, NC 27107, USA - D
1237 Silas Creek Pkwy
1237 Silas Creek Pkwy., Winston-Salem, NC 27127 (Hong Kong King Buffet)
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from St. Louis to Winston-Salem by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from St. Louis to Winston-Salem?
The cheapest bus tickets from St. Louis to Winston-Salem start from $114. The average price for this route is around $140. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from St. Louis to Winston-Salem?
The average bus trip duration from St. Louis to Winston-Salem is 1d 4h, covering a distance of 573 miles (924 km). The quickest bus can get you there in 19h 20m and is operated by Greyhound.
Which bus companies service the St. Louis to Winston-Salem route?
Several major bus companies operate on this route with 3 buses available per day.
What is the earliest and latest departure time for the bus from St. Louis to Winston-Salem?
The earliest bus departs from St. Louis to Winston-Salem at 2:00am. And the latest bus departs at 11:30pm.
What are the CO₂ emissions for the bus trip from St. Louis to Winston-Salem?
A bus trip from St. Louis to Winston-Salem generates an estimated 23 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from St. Louis to Winston-Salem was searched and found on Jan 25, 2026 with a price of $106To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Winston-Salem, as early as possible.
You can expect to pay from $106 to $216 for a bus ticket from St. Louis to Winston-Salem based on the last 2 days. You can expect to find the cheapest price for the trip at $113 which is on 2026-02-01.
