Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Tupelo (Brothers Quick Stop) | New Orleans Bus Station | Cheapest | ||||
| Bus | Tupelo (Brothers Quick Stop) | New Orleans Bus Station | Fastest | ||||
| Bus | Tupelo (Brothers Quick Stop) | New Orleans Bus Station | No tags |
Last refresh of the prices: Today at 11:40 AM CST.
Get from Tupelo to New Orleans
The journey takes about 17 hours 40 minutes and with fares starting at just $111, it presents an excellent value for a comfortable ride.
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Tupelo to New Orleans by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Tupelo to New Orleans?
The cheapest bus tickets from Tupelo to New Orleans start from $111. The average price for this route is around $171. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Tupelo to New Orleans?
The average bus trip duration from Tupelo to New Orleans is 17h 40m, covering a distance of 307 miles (495 km). The quickest bus can get you there in 12h 15m and is operated by Greyhound.
Which bus companies service the Tupelo to New Orleans route?
Several major train operators operate on this route with 2 trains available per day.
What is the earliest and latest departure time for the bus from Tupelo to New Orleans?
The earliest bus departs from Tupelo to New Orleans at 5:35am. And the latest bus departs at 11:15pm.
What are the CO₂ emissions for the bus trip from Tupelo to New Orleans?
A bus trip from Tupelo to New Orleans generates an estimated 12 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Tupelo to New Orleans was searched and found on Jan 14, 2026 with a price of $117To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tupelo to New Orleans, as early as possible.
You can expect to pay from $117 to $160 for a bus ticket from Tupelo to New Orleans based on the last 2 days. You can expect to find the cheapest price for the trip at $117 which is on 2026-01-14.
