Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Tupelo (Brothers Quick Stop) | New Orleans Bus Station | Cheapest | ||||
| Bus | Tupelo (Brothers Quick Stop) | New Orleans Bus Station | Fastest | ||||
| Bus | Tupelo (Brothers Quick Stop) | New Orleans Bus Station | No tags |
Last refresh of the prices: Today at 12:17 PM CST.
Get from Tupelo to New Orleans
The journey takes about 17 hours 40 minutes and with fares starting at just $95, it presents an excellent value for a comfortable ride.
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Tupelo to New Orleans by bus
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Tupelo to New Orleans was searched and found on Nov 24, 2025 with a price of $184To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tupelo to New Orleans, as early as possible.
You can expect to pay from $184 to $253 for a bus ticket from Tupelo to New Orleans based on the last 2 days. You can expect to find the cheapest price for the trip at $186 which is on 2025-11-26.
