Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Boston (South Station) | 1116 Woodruff Rd | Cheapest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Boston (South Station) | 1116 Woodruff Rd | Fastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Boston (South Station) | 1116 Woodruff Rd | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Brookline | 1116 Woodruff Rd | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Brookline | 1116 Woodruff Rd | No tags |
Last refresh of the prices: Last Monday at 10:38 PM EST.
Compare 2 ways to go from Boston to Greenville
Among the sustainable travel choices, the train stands out as a good way to reach Greenville. The journey takes about 20 hours 39 minutes, and with fares starting at just $279, it presents an excellent value for a comfortable ride.
Where are the popular stops in Boston and Greenville?
Stops in Boston
- A145 Dartmouth St, Boston, MA 02116, USA
- B100 Legends Way, Boston, MA 02114, USA
- C
Copley Square
115-127 St James Ave, Boston, MA 02116, USA - D
Prudential MBTA Station
220 Huntington Ave, Boston, MA 02115, USA - E
Copley MBTA Station
650 Boylston St, Boston, MA 02116, USA - F
Long Wharf
66 Long Wharf, Boston, MA 02110, USA
Stops in Greenville
- A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611 - B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607
Compare bus companies
Frequently asked questions about travelling from Boston, MA, US to Greenville, SC by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Boston to Greenville?
The cheapest bus tickets from Boston to Greenville start from $141. The average price for this route is around $224. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Boston to Greenville?
The average bus travel time from Boston to Greenville is 1d , covering a distance of 1282 km. The quickest bus can get you there in 20h 5m and is operated by FlixBus.
Which bus companies service the Boston to Greenville route?
What are the earliest and latest departure times for the bus from Boston to Greenville?
The earliest bus departs from Boston to Greenville at 1:30am. And the latest bus departs at 9:50pm.
What are the CO₂ emissions for the bus trip from Boston to Greenville?
A bus trip from Boston to Greenville generates an estimated 32 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Boston to Greenville?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 11799 reviews.
Which bus company has the best Wi-Fi from Boston to Greenville?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Boston to Greenville?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Boston to Greenville?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Boston, MA, US to Greenville, SC was searched and found on Jan 6, 2026 with a price of $150To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Boston, MA, US to Greenville, SC, as early as possible.
You can expect to pay from $150 to $272 for a bus ticket from Boston, MA, US to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at $191 which is on 2026-01-10.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Boston, MA, US to Greenville, SC?
The Bus is the cheapest travel choice for this destination
