Bus Tickets from Chicago to Des Moines

Next departures

Next departures for Chicago to Des Moines on October 11
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
Chicago 95Th & Dan Ryan
Des MoinesCheapest
Greyhound Lines, Inc.
Downtown Greyhound Station
Des MoinesFastest
Greyhound Lines, Inc.
Downtown Greyhound Station
Des MoinesNo tags
FlixBus + Greyhound Lines, Inc.
Chicago 95Th & Dan Ryan
Des MoinesNo tags
Greyhound Lines, Inc.
Downtown Greyhound Station
Des MoinesNo tags

Last refresh of the prices: Today at 4:51 AM CDT.

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Bus Chicago to Des Moines: Trip Overview

Average Ticket PriceUS$49
Average Bus Trip Duration9h 10m
Number of daily buses7
Earliest bus departure4:45am
Distance496 km
Latest bus departure11:50pm

Chicago to Des Moines Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Chicago to Des Moines.

Bus service from Chicago to Des Moines will be provided by the most trusted bus companies.

Whether it is cheap bus tickets or more luxurious buses going to Des Moines from Chicago, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Chicago - Des Moines

  1. What is the distance between Chicago and Des Moines?

    Chicago and Des Moines are 496 km (308 miles) apart.

  2. What are the departure and arrival locations for buses traveling from Chicago to Des Moines?

    Buses departing from Downtown Greyhound Station in Chicago will take you to Jefferson/Trailways Depot in Des Moines.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10-08
US$47
10-09
US$56
Today
US$53
10-11
US$59
10-12
US$51
10-13
US$58
10-14
US$43
10-15
US$38
busbud logoThe cheapest trip from Chicago to Des Moines was searched and found on Oct 15, 2025 with a price of US$38

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Des Moines, as early as possible.

You can expect to pay from US$38 to US$109 for a bus ticket from Chicago to Des Moines based on the last 2 days. You can expect to find the cheapest price for the trip at US$38 which is on 2025-10-15.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Chicago to Des Moines but it'll also be endearing to native speakers who will surely appreciate your effort.

Much more than a mere vehicle taking you from Chicago to Des Moines, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Chicago to Des Moines.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Chicago to Des Moines.

Did you know?

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Will you be returning to Chicago by bus?

Bus from Des Moines to Chicago

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