Bus Tickets from Chicago to St. Louis

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TodaySep 3
from US$57
TomorrowSep 4
from US$54
FriSep 5
from US$48
SatSep 6
from US$46
SunSep 7
from US$48
MonSep 8
from US$43
TueSep 9
from US$43
WedSep 10
from US$43

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: September 4 at
    Departure city: Chicago
    Departure location: Downtown Greyhound Station
    Arrival time: September 4 at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: September 4 at
    Departure city: Chicago
    Departure location: Chicago 95Th & Dan Ryan
    Arrival time: September 4 at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: September 4 at
    Departure city: Chicago
    Departure location: Downtown Greyhound Station
    Arrival time: September 4 at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: September 4 at
    Departure city: Chicago
    Departure location: Downtown Greyhound Station
    Arrival time: September 4 at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: September 4 at
    Departure city: Chicago
    Departure location: Chicago 95Th & Dan Ryan
    Arrival time: September 4 at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Compare 2 ways to go from Chicago to St. Louis

Bus
Average PriceUS$32 - US$263Average Duration7h 55m
10kg CO₂e5 out of 5 stars
Most eco-friendly
Train
Average PriceUS$30 - US$238Average Duration5h 1m
38kg CO₂e1 out of 5 stars
CheapestFastest
busbud logoBusbud recommends taking the train from Chicago to St. Louis

Among the sustainable travel choices, the train stands out as a good way to reach St. Louis. The journey takes about 5 hours 1 minute, and with fares starting at just US$30, it presents an excellent value for a comfortable ride.

4train per day
5h 1mAverage Duration
US$30Cheapest ticket
38kgCO₂ emissions

Bus Chicago to St. Louis: Trip Overview

Average Ticket PriceUS$49
Average Bus Trip Duration7h 55m
Number of daily buses13
Earliest bus departure12:15am
Distance408 km
Latest bus departure11:50pm

Chicago to St. Louis Bus

With Busbud, comparing and booking tickets for a bus from Chicago to St. Louis is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Chicago to St. Louis from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses travelling from Chicago to St. Louis, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Chicago - St. Louis

  1. What is the travel distance from Chicago to St. Louis?

    The distance between Chicago and St. Louis is approximately 419 km (260 miles).

  2. What are the departure and arrival locations for buses traveling from Chicago to St. Louis?

    Buses departing from Downtown Greyhound Station in Chicago will take you to Gateway Station in St. Louis.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09-01
US$169
09-02
US$57
Today
US$49
09-04
US$46
09-05
US$40
09-06
US$38
09-07
US$40
09-08
US$35
busbud logoThe cheapest trip from Chicago to St. Louis was searched and found on Sep 8, 2025 with a price of US$35

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to St. Louis, as early as possible.

You can expect to pay from US$35 to US$172 for a bus ticket from Chicago to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at US$35 which is on 2025-09-08.

Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Chicago to St. Louis.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Chicago to St. Louis, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Chicago to St. Louis that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Chicago to St. Louis.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Will you be returning to Chicago by bus?

Bus from St. Louis to Chicago

You can also go to St. Louis by train

Train from Chicago to St. Louis

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. Use Busbud to book your trip online, in your own language and currency, wherever you are. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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