Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Chicago 95Th & Dan Ryan | Jefferson City | CheapestFastest | ||||
| Bus | Downtown Greyhound Station | Jefferson City | No tags | ||||
| Bus | 537-517 W. Jackson Blvd | Jefferson City | No tags |
Last refresh of the prices: Yesterday at 8:25 PM CST.
Compare 2 ways to go from Chicago to Jefferson City
Among the sustainable travel choices, the train stands out as a good way to reach Jefferson City. The journey takes about 7 hours 46 minutes, and with fares starting at just $70, it presents an excellent value for a comfortable ride.
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Frequently asked questions about travelling from Chicago to Jefferson City, MO by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Chicago to Jefferson City?
The cheapest bus tickets from Chicago to Jefferson City start from $72. The average price for this route is around $110. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Chicago to Jefferson City?
The average bus travel time from Chicago to Jefferson City is 16h 50m, covering a distance of 532 km. The quickest bus can get you there in 16h 20m and is operated by Greyhound.
Which bus companies service the Chicago to Jefferson City route?
What are the earliest and latest departure times for the bus from Chicago to Jefferson City?
The earliest bus departs from Chicago to Jefferson City at 12:15am. And the latest bus departs at 11:40pm.
What are the CO₂ emissions for the bus trip from Chicago to Jefferson City?
A bus trip from Chicago to Jefferson City generates an estimated 13 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Chicago to Jefferson City?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87387 reviews.
Which bus company has the best Wi-Fi from Chicago to Jefferson City?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Chicago to Jefferson City?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Chicago to Jefferson City?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Chicago to Jefferson City, MO was searched and found on Dec 3, 2025 with a price of $105To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Jefferson City, MO, as early as possible.
You can expect to pay from $105 to $290 for a bus ticket from Chicago to Jefferson City, MO based on the last 2 days. You can expect to find the cheapest price for the trip at $105 which is on 2025-12-03.
