Bus from Chicago to Jefferson City, MO: Tickets & Schedules

Next bus departures

Next departures for Chicago to Jefferson City on December 2
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc.Bus
Chicago 95Th & Dan Ryan
Jefferson CityCheapestFastest
Greyhound Lines, Inc.Bus
Downtown Greyhound Station
Jefferson CityNo tags
Greyhound Lines, Inc.Bus
537-517 W. Jackson Blvd
Jefferson CityNo tags

Last refresh of the prices: Yesterday at 11:44 PM CST.

Compare 2 ways to go from Chicago to Jefferson City

We recommend taking the train

Among the sustainable travel choices, the train stands out as a good way to reach Jefferson City. The journey takes about 7 hours 46 minutes, and with fares starting at just $70, it presents an excellent value for a comfortable ride.

2train per day
7h 46mAverage Duration
532 kmDistance
48kgCO₂ emissions
Bus
Average Price$72 - $231Average Duration16h 50m
13kg CO₂e
Train
Average Price$70 - $262Average Duration7h 46m
48kg CO₂e

Frequently asked questions about travelling from Chicago to Jefferson City, MO by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

  1. How much is the bus ticket from Chicago to Jefferson City?

    The cheapest bus tickets from Chicago to Jefferson City start from $72. The average price for this route is around $110. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

  2. How long is the bus ride from Chicago to Jefferson City?

    The average bus travel time from Chicago to Jefferson City is 16h 50m, covering a distance of 532 km. The quickest bus can get you there in 16h 20m and is operated by Greyhound.

  3. Which bus companies service the Chicago to Jefferson City route?

    Several major bus companies operate on this route with 5 buses available per day, including services from Greyhound, FlixBus.

  4. What are the earliest and latest departure times for the bus from Chicago to Jefferson City?

    The earliest bus departs from Chicago to Jefferson City at 12:15am. And the latest bus departs at 11:40pm.

  5. What are the CO₂ emissions for the bus trip from Chicago to Jefferson City?

    A bus trip from Chicago to Jefferson City generates an estimated 13 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.

  6. What is the best bus company from Chicago to Jefferson City?

    According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87387 reviews.

  7. Which bus company has the best Wi-Fi from Chicago to Jefferson City?

    Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.

  8. Which bus company has the best on-time performance from Chicago to Jefferson City?

    According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.

  9. Which bus company has the cleanest buses from Chicago to Jefferson City?

    According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
11-29
$218
11-30
$284
Today
$215
12-02
$111
12-03
$109
12-04
$115
12-05
$134
12-06
$125
busbud logoThe cheapest trip from Chicago to Jefferson City, MO was searched and found on Dec 3, 2025 with a price of $109

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Jefferson City, MO, as early as possible.

You can expect to pay from $109 to $290 for a bus ticket from Chicago to Jefferson City, MO based on the last 2 days. You can expect to find the cheapest price for the trip at $109 which is on 2025-12-03.

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