Bus Tickets from Chicago to Jefferson City, MO

Next bus departures

Next departures for Chicago to Jefferson City on November 24
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
Jefferson CityCheapest
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Jefferson CityFastest
Greyhound Lines, Inc.Bus
Downtown Greyhound Station
Jefferson CityNo tags
Greyhound Lines, Inc.Bus
537-517 W. Jackson Blvd
Jefferson CityNo tags
Greyhound Lines, Inc.Bus
Chicago 95Th & Dan Ryan
Jefferson CityNo tags

Last refresh of the prices: Yesterday at 6:23 PM CST.

Compare 2 ways to go from Chicago to Jefferson City

We recommend taking the train

Among the sustainable travel choices, the train stands out as the good way to reach Jefferson City. The journey takes about 7 hours 46 minutes and with fares starting at just $49, it presents an excellent value for a comfortable ride.

1train per day
7h 46mAverage Duration
330 milesDistance
48kgCO₂ emissions
Average Price$51 - $175Average Duration17h 30m
13kg CO₂e
Average Price$49 - $147Average Duration7h 46m
48kg CO₂e

Frequently asked questions about traveling from Chicago to Jefferson City, MO by bus

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
11/21
$97
11/22
$95
Today
$114
11/24
$127
11/25
$119
11/26
$145
11/27
$83
11/28
$106
busbud logoThe cheapest trip from Chicago to Jefferson City, MO was searched and found on Nov 27, 2025 with a price of $83

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Jefferson City, MO, as early as possible.

You can expect to pay from $83 to $154 for a bus ticket from Chicago to Jefferson City, MO based on the last 2 days. You can expect to find the cheapest price for the trip at $83 which is on 2025-11-27.

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