What is the distance between Chicago and San Diego?

The distance covered from Chicago to San Diego is 2788 km (1729 miles).

What are the departure and arrival locations for buses traveling from Chicago to San Diego?

Buses traveling this route start their trip at Downtown Greyhound Station, in Chicago, and end it at Mission Valley Sheraton, in San Diego.

Bus Chicago to San Diego from $219 | Refundable Tickets

Next bus departures

Next departures for Chicago to San Diego on November 23
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
Greyhound Lines, Inc. + FlixBus	Bus	10:00pm	537-517 W. Jackson Blvd	3d 2h	10:15pm	Downtown SD (Seaport)	CheapestFastest

Next departures for Chicago to San Diego on November 24
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	11:50pm	Chicago 95Th & Dan Ryan	2d 16h	2:10pm	San Diego (Old Town-FlixBus)	Cheapest
FlixBus + Greyhound Lines, Inc.	Bus	5:10pm	Chicago 95Th & Dan Ryan	2d 2h	5:35pm	UCSD Health La Jolla Station	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	4:30pm	Downtown Greyhound Station	2d 3h	6:10pm	San Diego (Old Town-FlixBus)	No tags
	Bus	10:00am	537-517 W. Jackson Blvd	2d 15h	11:50pm	Greyhound Bus Stop	No tags
FlixBus + Greyhound Lines, Inc.	Bus	9:45am	Downtown Greyhound Station	2d 8h	3:55pm	UCSD Health La Jolla Station	No tags

Next departures for Chicago to San Diego on November 25
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	11:20am	Downtown Greyhound Station	2d 4h	1:40pm	UCSD Health La Jolla Station	Cheapest
FlixBus + Greyhound Lines, Inc.	Bus	5:10pm	Chicago 95Th & Dan Ryan	2d 2h	5:35pm	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	11:20am	Downtown Greyhound Station	2d 4h	2:10pm	San Diego (Old Town-FlixBus)	No tags
	Bus	10:00am	537-517 W. Jackson Blvd	2d 15h	11:50pm	Greyhound Bus Stop	No tags
FlixBus + Greyhound Lines, Inc.	Bus	4:30pm	Downtown Greyhound Station	2d 3h	6:10pm	San Diego (Old Town-FlixBus)	No tags

Next departures for Chicago to San Diego on November 27
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	11:20am	Downtown Greyhound Station	2d 4h	2:10pm	San Diego (Old Town-FlixBus)	Cheapest
FlixBus + Greyhound Lines, Inc.	Bus	5:10pm	Chicago 95Th & Dan Ryan	2d 2h	5:35pm	UCSD Health La Jolla Station	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	4:30pm	Downtown Greyhound Station	2d 3h	6:10pm	San Diego (Old Town-FlixBus)	No tags
	Bus	10:00am	537-517 W. Jackson Blvd	2d 9h	5:45pm	Greyhound Bus Stop	No tags
Greyhound Lines, Inc. + FlixBus	Bus	11:20am	Downtown Greyhound Station	2d 4h	1:40pm	UCSD Health La Jolla Station	No tags

Last refresh of the prices: Last Friday at 11:30 PM CST.

Compare 2 ways to go from Chicago to San Diego

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach San Diego. The journey takes about 2 days, 7 hours 45 minutes, and with fares starting at just $171, it presents an excellent value for a comfortable ride.

21bus per day

2d 7hAverage Duration

2782 kmDistance

70kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$171 - $841	Average Duration2d 7h	CO₂ emissions 70kg CO₂e
Train	Average Price$269 - $2,236	Average Duration2d	CO₂ emissions 254kg CO₂e

Where are the popular stops in Chicago and San Diego?

Stops in Chicago

A
Downtown Greyhound Station
630 W Harrison St, Chicago, IL 60607, USA
Visit page
B
Chicago O'Hare International Airport
Visit page
C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA
D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA
E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA
F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA

Stops in San Diego

A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA
B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA
C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA
D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA
E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA
F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA

Compare bus companies

Greyhound

3.5/587,391 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

FlixBus

3.5/511,413 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about travelling from Chicago to San Diego, CA, US by bus

What is the distance between Chicago and San Diego?
The distance covered from Chicago to San Diego is 2788 km (1729 miles).
What are the departure and arrival locations for buses traveling from Chicago to San Diego?
Buses traveling this route start their trip at Downtown Greyhound Station, in Chicago, and end it at Mission Valley Sheraton, in San Diego.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11-21

$650

11-22

$615

Today

$625

11-24

$693

11-25

$410

11-26

No data

11-27

$443

11-28

$432

The cheapest trip from Chicago to San Diego, CA, US was searched and found on Nov 25, 2025 with a price of $410

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to San Diego, CA, US, as early as possible.

You can expect to pay from $410 to $693 for a bus ticket from Chicago to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $410 which is on 2025-11-25.