Next departures for Chicago to Syracuse on November 22
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
Syracuse (Regional Transportation Center)
Cheapest
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Syracuse (Regional Transportation Center)
Fastest
Next departures for Chicago to Syracuse on November 23
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
Syracuse (Regional Transportation Center)
Cheapest
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Syracuse (Regional Transportation Center)
Fastest
Greyhound Lines, Inc. + FlixBus
Bus
537-517 W. Jackson Blvd
Syracuse (Regional Transportation Center)
No tags
Next departures for Chicago to Syracuse on November 24
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Syracuse (Regional Transportation Center)
CheapestFastest
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
Syracuse (Regional Transportation Center)
No tags
Greyhound Lines, Inc. + FlixBus
Bus
537-517 W. Jackson Blvd
Syracuse (Regional Transportation Center)
No tags
Next departures for Chicago to Syracuse on November 25
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
Syracuse (Regional Transportation Center)
Cheapest
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Syracuse (Regional Transportation Center)
Fastest
Greyhound Lines, Inc. + FlixBus
Bus
537-517 W. Jackson Blvd
Syracuse (Regional Transportation Center)
No tags
Next departures for Chicago to Syracuse on November 26
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
Syracuse (Regional Transportation Center)
Cheapest
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Syracuse (Regional Transportation Center)
Fastest
Greyhound Lines, Inc. + FlixBus
Bus
537-517 W. Jackson Blvd
Syracuse (Regional Transportation Center)
No tags
Next departures for Chicago to Syracuse on November 27
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Syracuse (Regional Transportation Center)
CheapestFastest
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
Syracuse (Regional Transportation Center)
No tags
Greyhound Lines, Inc. + FlixBus
Bus
537-517 W. Jackson Blvd
Syracuse (Regional Transportation Center)
No tags
Next departures for Chicago to Syracuse on November 28
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Chicago 95Th & Dan Ryan
Syracuse (Regional Transportation Center)
CheapestFastest
Bus
Downtown Greyhound Station
Syracuse (Regional Transportation Center)
No tags
Greyhound Lines, Inc. + FlixBus
Bus
537-517 W. Jackson Blvd
Syracuse (Regional Transportation Center)
No tags
Next departures for Chicago to Syracuse on November 29
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
Syracuse (Regional Transportation Center)
Cheapest
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Syracuse (Regional Transportation Center)
Fastest
Greyhound Lines, Inc. + FlixBus
Bus
537-517 W. Jackson Blvd
Syracuse (Regional Transportation Center)
No tags
Last refresh of the prices: Yesterday at 9:34 PM CST.
Compare 2 ways to go from Chicago to Syracuse
We recommend taking the train
Among the sustainable travel choices, the train stands out as a good way to reach Syracuse. The journey takes about 12 hours 58 minutes, and with fares starting at just $86, it presents an excellent value for a comfortable ride.
Based on 11400 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the WiFi. FlixBus ticket prices on this trip start at $233
Based on 87388 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $121
Frequently asked questions about travelling from Chicago to Syracuse, US by bus
How far is Chicago from Syracuse?
The distance between Chicago and Syracuse is approximately 954 km (592 miles).
What are the departure and arrival locations for buses traveling from Chicago to Syracuse?
Buses departing from Downtown Greyhound Station in Chicago will take you to Regional Transportation Center in Syracuse.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11-20
No data
11-21
No data
Today
No data
11-23
$139
11-24
$142
11-25
$142
11-26
$149
11-27
No data
The cheapest trip from Chicago to Syracuse, US was searched and found on Nov 23, 2025 with a price of $139
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Syracuse, US, as early as possible.
You can expect to pay from $139 to $149 for a bus ticket from Chicago to Syracuse, US based on the last 2 days. You can expect to find the cheapest price for the trip at $139 which is on 2025-11-23.
The cheapest trip from Chicago to Syracuse, US was searched and found on Nov 23, 2025 with a price of $139
