Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus
| Chicago 95Th & Dan Ryan | Syracuse (Regional Transportation Center) | Cheapest | ||||
 | Bus
| Downtown Greyhound Station | Syracuse (Regional Transportation Center) | Fastest | ||||
 | Bus
| Downtown Greyhound Station | Syracuse (Regional Transportation Center) | No tags | ||||
| Bus
| 537-517 W. Jackson Blvd | Syracuse (Regional Transportation Center) | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus
| Chicago 95Th & Dan Ryan | Syracuse (Regional Transportation Center) | No tags |
Last refresh of the prices: Yesterday at 5:15 PM CDT.
Compare 2 ways to go from Chicago to Syracuse
Among the sustainable travel choices, the Train stands out as a good way to reach Syracuse. The journey takes about 12 hours 58 minutes and with fares starting at just PEN 268, it presents an excellent value for a comfortable ride.
Bus stations and stops in Chicago and Syracuse
Stops in Chicago
- A
Downtown Greyhound Station
630 W Harrison St, Chicago, IL 60607, USA - C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Stops in Syracuse
- A
Regional Transportation Center
1 Walsh Circle Ste 30, Syracuse, NY 13208 - C
Syracuse University
Bus stops at Schine Student Center across the street from the Sheraton Parking Garage., Schine Student Center, 303 University Pl, Syracuse, NY 13210 - D
Syracuse University - Lyman Hall
College Place, Syracuse, NY 13210, USA - E
New York State Fairgrounds
581 State Fair Blvd, Syracuse, NY 13209, USA - F
Syracuse, NY
349-399 US-11, Syracuse, NY 13202, USA
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Frequently asked questions about traveling from Chicago to Syracuse, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Chicago to Syracuse?
The cheapest bus tickets from Chicago to Syracuse start from PEN 241. The average price for this route is around PEN 361. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Chicago to Syracuse?
The average bus trip duration from Chicago to Syracuse is 23h 45m, covering a distance of 590 miles (951 km). The quickest bus can get you there in 12h 58m and is operated by Amtrak.
Which bus companies service the Chicago to Syracuse route?
What is the earliest and latest departure time for the bus from Chicago to Syracuse?
The earliest bus departs from Chicago to Syracuse at 10:15am. And the latest bus departs at 7:40pm.
What are the CO₂ emissions for the bus trip from Chicago to Syracuse?
A bus trip from Chicago to Syracuse generates an estimated 23.768549999999998 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Chicago to Syracuse?
According to Busbud customers, the highest-rated bus company on this route is Amtrak, with an average rating of 4.1 out of 5 stars based on 6497 reviews.
Which bus company has the best Wi-Fi from Chicago to Syracuse?
Based on reviews on Busbud, the bus company Amtrak has the best Wi-Fi rating with a score of 3.6.
Which bus company has the most timely service from Chicago to Syracuse?
According to Busbud traveler reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Chicago to Syracuse?
According to Busbud traveler reviews, the bus company with the cleanest buses on this route is Amtrak, with a cleanliness rating of 4.5 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Chicago to Syracuse, US was searched and found on Oct 6, 2026 with a price of PEN 315To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Syracuse, US, as early as possible.
You can expect to pay from PEN 315 to PEN 753 for a bus ticket from Chicago to Syracuse, US based on the last 2 days. You can expect to find the cheapest price for the trip at PEN 315 which is on 2026-10-06.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Chicago to Syracuse, US?
The Bus is the cheapest travel choice for this destination
