Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus
| Chicago 95Th & Dan Ryan | Tupelo (Brothers Quick Stop) | Cheapest | ||||
 | Bus
| Downtown Greyhound Station | Tupelo (Brothers Quick Stop) | Fastest | ||||
| Bus
| Downtown Greyhound Station | Tupelo (Brothers Quick Stop) | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus
| Chicago 95Th & Dan Ryan | Tupelo (Brothers Quick Stop) | No tags | ||||
| Bus
| 537-517 W. Jackson Blvd | Tupelo (Brothers Quick Stop) | No tags | ||||
| Bus
| Chicago 95Th & Dan Ryan | Tupelo (Brothers Quick Stop) | No tags |
Last refresh of the prices: Yesterday at 2:34 AM CDT.
Get from Chicago to Tupelo
The journey takes about 17 hours 20 minutes, and with fares starting at just PEN 219, it presents an excellent value for a comfortable ride.
Compare bus companies
Based on 88134 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi‑Fi. Greyhound ticket prices on this trip start at PEN 267
Frequently asked questions about travelling from Chicago to Tupelo by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Chicago to Tupelo?
The cheapest bus tickets from Chicago to Tupelo start from PEN 219. The average price for this route is around PEN 289. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Chicago to Tupelo?
The average bus travel time from Chicago to Tupelo is 17h 20m, covering a distance of 845 km. The quickest bus can get you there in 12h and is operated by Greyhound.
Which bus companies service the Chicago to Tupelo route?
Several major bus companies operate on this route with 5 buses available per day.
What are the earliest and latest departure times for the bus from Chicago to Tupelo?
The earliest bus departs from Chicago to Tupelo at 5:15am. And the latest bus departs at 11:55pm.
What are the CO₂ emissions for the bus trip from Chicago to Tupelo?
A bus trip from Chicago to Tupelo generates an estimated 21.120275000000003 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Chicago to Tupelo was searched and found on Sep 15, 2026 with a price of PEN 242To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Tupelo, as early as possible.
You can expect to pay from PEN 242 to PEN 460 for a bus ticket from Chicago to Tupelo based on the last 2 days. You can expect to find the cheapest price for the trip at PEN 242 which is on 2026-09-15.
