Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Chicago 95Th & Dan Ryan | Tupelo (Brothers Quick Stop) | Cheapest | ||||
 | Bus | Downtown Greyhound Station | Tupelo (Brothers Quick Stop) | Fastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Downtown Greyhound Station | Tupelo (Brothers Quick Stop) | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Chicago 95Th & Dan Ryan | Tupelo (Brothers Quick Stop) | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Chicago 95Th & Dan Ryan | Tupelo (Brothers Quick Stop) | No tags |
Last refresh of the prices: Yesterday at 12:31 PM CDT.
Get from Chicago to Tupelo
The journey takes about 17 hours 20 minutes and with fares starting at just COP 264,065, it presents an excellent value for a comfortable ride.
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Chicago to Tupelo by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Chicago to Tupelo?
The cheapest bus tickets from Chicago to Tupelo start from COP 264,065. The average price for this route is around COP 433,760. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Chicago to Tupelo?
The average bus trip duration from Chicago to Tupelo is 17h 20m, covering a distance of 523 miles (844 km). The quickest bus can get you there in 12h and is operated by Greyhound.
Which bus companies service the Chicago to Tupelo route?
Several major bus companies operate on this route with 5 buses available per day.
What is the earliest and latest departure time for the bus from Chicago to Tupelo?
The earliest bus departs from Chicago to Tupelo at 5:25am. And the latest bus departs at 11:55pm.
What are the CO₂ emissions for the bus trip from Chicago to Tupelo?
A bus trip from Chicago to Tupelo generates an estimated 21.081274999999998 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Chicago to Tupelo was searched and found on Jul 28, 2026 with a price of COP 314,611To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Tupelo, as early as possible.
You can expect to pay from COP 314,611 to COP 830,285 for a bus ticket from Chicago to Tupelo based on the last 2 days. You can expect to find the cheapest price for the trip at COP 314,611 which is on 2026-07-28.
