Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Detroit Bus Station | 1116 Woodruff Rd | Cheapest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Detroit Bus Station | 1116 Woodruff Rd | Fastest |
Last refresh of the prices: Yesterday at 8:48 AM EST.
Compare 2 ways to go from Detroit to Greenville
Among the sustainable travel choices, the Bus stands out as a good way to reach Greenville. The journey takes about 1 day, 25 minutes, and with fares starting at just $122, it presents an excellent value for a comfortable ride.
Where are the popular stops in Detroit and Greenville?
Stops in Greenville
- A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611 - B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607
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Frequently asked questions about travelling from Detroit, MI to Greenville, SC by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Detroit to Greenville?
The cheapest bus tickets from Detroit to Greenville start from $122. The average price for this route is around $193. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Detroit to Greenville?
The average bus travel time from Detroit to Greenville is 1d , covering a distance of 837 km. The quickest bus can get you there in 18h 20m and is operated by Greyhound.
Which bus companies service the Detroit to Greenville route?
What are the earliest and latest departure times for the bus from Detroit to Greenville?
The earliest bus departs from Detroit to Greenville at 6:40am. And the latest bus departs at 11:25pm.
What are the CO₂ emissions for the bus trip from Detroit to Greenville?
A bus trip from Detroit to Greenville generates an estimated 21 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Detroit to Greenville?
According to Busbud customers, the highest-rated bus company on this route is Amtrak, with an average rating of 4.1 out of 5 stars based on 5733 reviews.
Which bus company has the best Wi-Fi from Detroit to Greenville?
Based on Busbud reviews, the bus company Amtrak has the highest Wi-Fi rating with a score of 3.6.
Which bus company has the best on-time performance from Detroit to Greenville?
According to Busbud traveller reviews, the most punctual bus company on this route is Amtrak, with a punctuality rating of 3.8 out of 5 stars.
Which bus company has the cleanest buses from Detroit to Greenville?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Amtrak, with a cleanliness rating of 4.5 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Detroit, MI to Greenville, SC was searched and found on Jan 28, 2026 with a price of $112To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Detroit, MI to Greenville, SC, as early as possible.
You can expect to pay from $112 to $1,112 for a bus ticket from Detroit, MI to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at $112 which is on 2026-01-28.
Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Detroit, MI to Greenville, SC?
The Bus is the cheapest travel choice for this destination
