Bus Tickets from Detroit, MI to Greenville, SC

Previously seen trips

Next departures for Detroit to Greenville on October 10
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus
Detroit Bus Station
1116 Woodruff RdNo tags
Greyhound
Detroit Bus Station
1116 Woodruff RdNo tags
Greyhound
Detroit Bus Station
1116 Woodruff RdNo tags
FlixBus + Greyhound
Detroit Bus Station
1116 Woodruff RdNo tags
Greyhound
Detroit Bus Station
1116 Woodruff RdNo tags

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to go from Detroit to Greenville.

Bus
Average Price$85 - $213Average Duration18h 20m
21kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average Price$222 - $402Average Duration1d 19h
76kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Detroit to Greenville

Among the sustainable travel choices, the bus stands out as the good way to reach Greenville. The journey takes about 18 hours 20 minutes and with fares starting at just $85, it presents an excellent value for a comfortable ride.

2bus per day
18h 20mAverage Duration
$85Cheapest ticket
21kgCO₂ emissions

Bus Detroit, MI to Greenville, SC: Trip Overview

Average ticket price$102
Average bus trip duration18h 20m
Number of daily buses2
Earliest bus departure6:40am
Distance519 miles (836 km)
Latest bus departure8:15pm

Detroit to Greenville Bus

With Busbud, comparing and booking tickets for a bus from Detroit to Greenville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from Detroit to Greenville will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses traveling from Detroit to Greenville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip Detroit, MI - Greenville, SC

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10/08
No data
10/09
$114
Today
No data
10/11
No data
10/12
No data
10/13
No data
10/14
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10/15
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busbud logoThe cheapest trip from Detroit, MI to Greenville, SC was searched and found on Oct 9, 2025 with a price of $114

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Detroit, MI to Greenville, SC, as early as possible.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Detroit to Greenville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from Detroit to Greenville, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Detroit to Greenville that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Detroit to Greenville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

What's the cheapest way to go from Detroit, MI to Greenville, SC?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Detroit, MI by bus?

Bus from Greenville, SC to Detroit, MI

You can also go to Greenville, SC by train

Train from Detroit, MI to Greenville, SC

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travelers find a bus, plot routes, and book intercity bus tickets all over the world. Use Busbud to book your trip online, in your own language and currency, wherever you are. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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