Find coaches from Detroit, MI to Greenville, SC

Find affordable coach tickets from Detroit, MI to Greenville, SC with flexible options. Book your journey now

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Today2 Aug
Tomorrow3 Aug
Mon4 Aug
from US$114
Tue5 Aug
from US$102
Wed6 Aug
Thu7 Aug
Fri8 Aug
Sat9 Aug

Next departures to Greenville

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: 4 August at
    Departure city: Detroit
    Departure location: Detroit Bus Station
    Arrival time: 5 August at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 4 August at
    Departure city: Detroit
    Departure location: Amtrak Station
    Arrival time: 6 August at
    Destination city: Greenville
    Destination location: Greenville Station
    Operated by: AmtrakAmtrak
    Vehicle: BusDuration:
  • Departure time: 4 August at
    Departure city: Detroit
    Departure location: Detroit Bus Station
    Arrival time: 5 August at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 4 August at
    Departure city: Detroit
    Departure location: Amtrak Station
    Arrival time: 6 August at
    Destination city: Greenville
    Destination location: Greenville Station
    Operated by: AmtrakAmtrak
    Vehicle: BusDuration:

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Compare 2 ways to travel from Detroit to Greenville

Bus
Average priceUS$85 - US$219Average duration18h 20m
21kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average priceUS$357 - US$591Average duration1d 19h
76kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Detroit to Greenville

Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 18 hours 20 minutes and with fares starting at just US$85, it presents an excellent value for a comfortable ride.

1bus per day
18h 20mAverage duration
US$85Cheapest ticket
21kgCO₂ emissions

Bus Detroit, MI to Greenville, SC: Trip Overview

Average ticket priceUS$114
Average bus trip duration18h 20m
Number of daily buses1
Earliest bus departure06:40
Distance519 miles
Latest bus departure20:15

Detroit to Greenville Bus

With Busbud, comparing and booking tickets for a bus from Detroit to Greenville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from Detroit to Greenville will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses travelling from Detroit to Greenville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Detroit, MI - Greenville, SC

  1. How far is Greenville from Detroit by coach?

    The journey from Detroit to Greenville by coach covers an approximate distance of 518 miles (835 km).

  2. What is the best way to go from Detroit to Greenville without flying?

    To travel from Detroit to Greenville without flying, you can take the coaches. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
31/07
No data
01/08
US$83
Today
US$78
03/08
No data
04/08
US$107
05/08
US$95
06/08
No data
07/08
US$87
busbud logoThe cheapest trip from Detroit, MI to Greenville, SC was searched and found on 2 Aug 2025 with a price of US$78

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Detroit, MI to Greenville, SC as early as possible.

You can expect to pay from US$78 to US$1,260 for a bus ticket from Detroit, MI to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at US$87, which is on 2025-08-07.

Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Detroit to Greenville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from Detroit to Greenville, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Detroit to Greenville that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Detroit to Greenville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

What's the cheapest way to go from Detroit, MI to Greenville, SC?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Detroit, MI by bus?

Bus from Detroit, MI to Greenville, SC

You can also go to Greenville, SC by train

Train from Detroit, MI to Greenville, SC

Why choose Busbud?

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