Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound | Bus | Florence, SC | Syracuse (Regional Transportation Center) | No tags | ||||
FlixBus + Greyhound | Bus | Florence, SC | Syracuse (Regional Transportation Center) | No tags | ||||
Greyhound + FlixBus | Bus | Florence, SC | Syracuse (Regional Transportation Center) | No tags | ||||
Greyhound + FlixBus | Bus | Florence, SC | Syracuse (Regional Transportation Center) | No tags | ||||
Greyhound + FlixBus | Bus | Bus station | Syracuse (Regional Transportation Center) | No tags |
Compare 2 ways to go from Florence to Syracuse
Among the sustainable travel choices, the Bus stands out as a good way to reach Syracuse. The journey takes about 21 hours 5 minutes, and with fares starting at just $155, it presents an excellent value for a comfortable ride.
Where are the popular stops in Florence and Syracuse?
Stops in Florence
- A619 S Irby St, Florence, SC 29501, USA
- B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
Stops in Syracuse
- A
Regional Transportation Center
1 Walsh Circle Ste 30, Syracuse, NY 13208 - CBus stops at Schine Student Center across the street from the Sheraton Parking Garage., Schine Student Center, 303 University Pl, Syracuse, NY 13210
- D
Syracuse University - Lyman Hall
College Place, Syracuse, NY 13210, USA - E
New York State Fairgrounds
581 State Fair Blvd, Syracuse, NY 13209, USA - F
Syracuse, NY
349-399 US-11, Syracuse, NY 13202, USA
Compare bus companies
Based on 87531 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi‑Fi. Greyhound ticket prices on this trip start at $306
Frequently asked questions about travelling from Florence, SC, US to Syracuse, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Florence to Syracuse?
The cheapest bus tickets from Florence to Syracuse start from $155. The average price for this route is around $167. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Florence to Syracuse?
The average bus travel time from Florence to Syracuse is 21h 5m, covering a distance of 1036 km. The quickest bus can get you there in 21h 15m and is operated by Greyhound.
Which bus companies service the Florence to Syracuse route?
Several major bus companies operate on this route with 2 buses available per day.
What are the earliest and latest departure times for the bus from Florence to Syracuse?
The earliest bus departs from Florence to Syracuse at 12:05am. And the latest bus departs at 4:30pm.
What are the CO₂ emissions for the bus trip from Florence to Syracuse?
A bus trip from Florence to Syracuse generates an estimated 25.885125 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Florence, SC, US to Syracuse, US was searched and found on Mar 31, 2026 with a price of $162To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Syracuse, US, as early as possible.
What's the cheapest way to go from Florence, SC, US to Syracuse, US?
The Bus is the cheapest travel choice for this destination
