How much is the bus ticket from Florence to Syracuse?

The cheapest bus tickets from Florence to Syracuse start from $141. The average price for this route is around $215. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from Florence to Syracuse?

The average bus trip duration from Florence to Syracuse is 21h 15m, covering a distance of 643 miles (1037 km). The quickest bus can get you there in 19h 31m and is operated by FlixBus .

Which bus companies service the Florence to Syracuse route?

Several major bus companies operate on this route with 2 buses available per day, including services from Greyhound , FlixBus .

What is the earliest and latest departure time for the bus from Florence to Syracuse?

The earliest bus departs from Florence to Syracuse at 12:05am. And the latest bus departs at 4:30pm.

What are the CO₂ emissions for the bus trip from Florence to Syracuse?

A bus trip from Florence to Syracuse generates an estimated 26 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

What is the best bus company from Florence to Syracuse?

According to Busbud customers, the highest-rated bus company on this route is Greyhound , with an average rating of 3.5 out of 5 stars based on 87412 reviews.

Which bus company has the best Wi-Fi from Florence to Syracuse?

Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.

Which bus company has the most timely service from Florence to Syracuse?

According to Busbud traveller reviews, the most timely bus company on this route is FlixBus , with a punctuality rating of 3.9 out of 5 stars.

Which bus company has the cleanest buses from Florence to Syracuse?

According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus , with a cleanliness rating of 4.1 out of 5 stars.

Bus Florence to Syracuse from $207 | Refundable Tickets

Previously seen trips

Next departures for Florence to Syracuse on December 15
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound	Bus	11:59pm	Florence, SC	19h 31m	7:30pm	Syracuse (Regional Transportation Center)	No tags
Greyhound + FlixBus	Bus	11:59pm	Florence, SC	19h 31m	7:30pm	Syracuse (Regional Transportation Center)	No tags
FlixBus + Greyhound	Bus	5:35am	Florence, SC	1d 5h	11:20am	Syracuse (Regional Transportation Center)	No tags
FlixBus + Greyhound	Bus	11:59pm	Florence, SC	19h 31m	7:30pm	Syracuse (Regional Transportation Center)	No tags
Greyhound + FlixBus	Bus	5:30am	Florence, SC	1d 9h	3:15pm	Syracuse (Regional Transportation Center)	No tags

Compare 2 ways to go from Florence to Syracuse

We recommend taking the train

Among the sustainable travel choices, the train stands out as the good way to reach Syracuse. The journey takes about 19 hours 27 minutes and with fares starting at just $226, it presents an excellent value for a comfortable ride.

2train per day

19h 27mAverage Duration

642 milesDistance

94kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$141 - $447	Average Duration21h 15m	CO₂ emissions 26kg CO₂e
Train	Average Price$226 - $420	Average Duration19h 27m	CO₂ emissions 94kg CO₂e

Where are the popular stops in Florence and Syracuse?

Stops in Florence

A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA
Visit page
B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA

Stops in Syracuse

A
Regional Transportation Center
1 Walsh Circle Ste 30, Syracuse, NY 13208
Visit page
B
Syracuse Airport
Visit page
C
Syracuse University
Bus stops at Schine Student Center across the street from the Sheraton Parking Garage., Schine Student Center, 303 University Pl, Syracuse, NY 13210
Visit page
D
Syracuse University - Lyman Hall
College Place, Syracuse, NY 13210, USA
E
New York State Fairgrounds
581 State Fair Blvd, Syracuse, NY 13209, USA
F
Syracuse, NY
349-399 US-11, Syracuse, NY 13202, USA

Compare bus companies

Greyhound

3.5/587,431 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

FlixBus

3.5/511,615 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Big Sky

Frequently asked questions about traveling from Florence, SC, US to Syracuse, US by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Florence to Syracuse?
The cheapest bus tickets from Florence to Syracuse start from $141. The average price for this route is around $215. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Florence to Syracuse?
The average bus trip duration from Florence to Syracuse is 21h 15m, covering a distance of 643 miles (1037 km). The quickest bus can get you there in 19h 31m and is operated by FlixBus.
Which bus companies service the Florence to Syracuse route?
Several major bus companies operate on this route with 2 buses available per day, including services from Greyhound, FlixBus.
What is the earliest and latest departure time for the bus from Florence to Syracuse?
The earliest bus departs from Florence to Syracuse at 12:05am. And the latest bus departs at 4:30pm.
What are the CO₂ emissions for the bus trip from Florence to Syracuse?
A bus trip from Florence to Syracuse generates an estimated 26 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Florence to Syracuse?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87412 reviews.
Which bus company has the best Wi-Fi from Florence to Syracuse?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Florence to Syracuse?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Florence to Syracuse?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

12/12

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12/13

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Today

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12/15

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12/18

$207

12/19

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The cheapest trip from Florence, SC, US to Syracuse, US was searched and found on Dec 18, 2025 with a price of $207

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Syracuse, US, as early as possible.

You can expect to pay from $207 to $207 for a bus ticket from Florence, SC, US to Syracuse, US based on the last 2 days. You can expect to find the cheapest price for the trip at $207 which is on 2025-12-18.