Bus Tickets from Gainesville, FL to Greenville, SC

TomorrowAug 1
SatAug 2
SunAug 3
MonAug 4
TueAug 5
from US$73
WedAug 6
from US$66
ThuAug 7
FriAug 8

Cheap buses leaving Tuesday

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: August 5 at
    Departure city: Gainesville
    Departure location: Rosa Parks Station
    Arrival time: August 5 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 5 at
    Departure city: Gainesville
    Departure location: Gainesville Bus Stop
    Arrival time: August 5 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: August 5 at
    Departure city: Gainesville
    Departure location: Gainesville Bus Stop
    Arrival time: August 6 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 5 at
    Departure city: Gainesville
    Departure location: Rosa Parks Station
    Arrival time: August 5 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: August 5 at
    Departure city: Gainesville
    Departure location: Rosa Parks Station
    Arrival time: August 6 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

Last refresh of the prices: Last Tuesday at 7:18 AM EDT.

Prices and availability are subject to change.

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus Gainesville, FL to Greenville, SC: Trip Overview

Average Ticket PriceUS$120
Average Bus Trip Duration12h 20m
Number of daily buses5
Earliest bus departure1:10am
Distance576 km
Latest bus departure10:40pm

Gainesville to Greenville Bus

With Busbud, comparing and booking tickets for a bus from Gainesville to Greenville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from Gainesville to Greenville.

From cheap bus tickets to more luxurious buses travelling from Gainesville to Greenville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Gainesville, FL - Greenville, SC

  1. How far is Gainesville from Greenville?

    The distance covered from Gainesville to Greenville is 579 km (359 miles).

  2. What are the departure and arrival locations for buses traveling from Gainesville to Greenville?

    Buses traveling this route start their trip at Rosa Parks Station, in Gainesville, and end it at Guadalajara Supermarket Bus Stop, in Greenville.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
07-29
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07-30
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Today
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08-01
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08-02
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08-03
US$70
08-04
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08-05
US$69
busbud logoThe cheapest trip from Gainesville, FL to Greenville, SC was searched and found on Aug 5, 2025 with a price of US$69

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Gainesville, FL to Greenville, SC, as early as possible.

You can expect to pay from US$69 to US$71 for a bus ticket from Gainesville, FL to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at US$69 which is on 2025-08-05.

Usually Greyhound Lines, Inc. will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Gainesville to Greenville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Gainesville to Greenville.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Gainesville to Greenville that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Gainesville to Greenville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Will you be returning to Gainesville, FL by bus?

Bus from Gainesville, FL to Greenville, SC

You can also go to Greenville, SC by train

Train from Gainesville, FL to Greenville, SC

Why choose Busbud?

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