Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | 1116 Woodruff Rd | Pittsburgh Intermodal Station | CheapestFastest | ||||
 | Bus | 1116 Woodruff Rd | Pittsburgh Intermodal Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | 1116 Woodruff Rd | Pittsburgh Intermodal Station | No tags |
Last refresh of the prices: Today at 10:08 AM EST.
Compare 2 ways to go from Greenville to Pittsburgh
Among the sustainable travel choices, the bus stands out as a good way to reach Pittsburgh. The journey takes about 18 hours, and with fares starting at just $159, it presents an excellent value for a comfortable ride.
Where are the popular stops in Greenville and Pittsburgh?
Stops in Greenville
- A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611 - B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607
Stops in Pittsburgh
- A55 11th St, Pittsburgh, PA 15222, USA
- B
Sennott Square
201 S Bouquet St, Pittsburgh, PA 15213, USA
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Frequently asked questions about travelling from Greenville, SC to Pittsburgh by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Greenville to Pittsburgh?
The cheapest bus tickets from Greenville to Pittsburgh start from $159. The average price for this route is around $212. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Greenville to Pittsburgh?
The average bus travel time from Greenville to Pittsburgh is 18h, covering a distance of 657 km. The quickest bus can get you there in 17h 5m and is operated by FlixBus.
Which bus companies service the Greenville to Pittsburgh route?
What are the earliest and latest departure times for the bus from Greenville to Pittsburgh?
The earliest bus departs from Greenville to Pittsburgh at 10:50am. And the latest bus departs at 10:00pm.
What are the CO₂ emissions for the bus trip from Greenville to Pittsburgh?
A bus trip from Greenville to Pittsburgh generates an estimated 16 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Greenville to Pittsburgh?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 11504 reviews.
Which bus company has the best Wi-Fi from Greenville to Pittsburgh?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Greenville to Pittsburgh?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Greenville to Pittsburgh?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Greenville, SC to Pittsburgh was searched and found on Dec 14, 2025 with a price of $150To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Pittsburgh, as early as possible.
You can expect to pay from $150 to $202 for a bus ticket from Greenville, SC to Pittsburgh based on the last 2 days. You can expect to find the cheapest price for the trip at $195 which is on 2025-12-15.
What's the cheapest way to go from Greenville, SC to Pittsburgh?
The bus is the cheapest travel choice for this destination
