Bus Tickets from Medford, OR to San Francisco, US

Previously seen trips

Next departures for Medford to San Francisco on October 13
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound
Medford Airport
409 Townsend St, SFNo tags
Greyhound
Medford Airport
San Francisco Bus StationNo tags
Greyhound + FlixBus
Medford Airport
409 Townsend St, SFNo tags
Greyhound
Medford Airport
San Francisco Bus StationNo tags
Greyhound
Medford Airport
San Francisco Bus StationNo tags

Accepted payments

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  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus Medford, OR to San Francisco, US: Trip Overview

Average Ticket PriceUS$106
Average Bus Trip Duration10h
Number of daily buses2
Earliest bus departure8:05am
Distance511 km

Medford to San Francisco Bus

With Busbud, comparing and booking tickets for a bus from Medford to San Francisco is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Medford to San Francisco from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses travelling from Medford to San Francisco, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Medford, OR - San Francisco, US

  1. What is the travel distance from Medford to San Francisco?

    Medford and San Francisco are 504 km (313 miles) apart.

  2. What are the departure and arrival locations for buses traveling from Medford to San Francisco?

    Buses departing from Front Street Station in Medford will take you to Hyde/Beach (Fisherman's Wharf) in San Francisco.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10-10
US$97
10-11
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Today
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10-13
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10-14
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10-15
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10-16
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10-17
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busbud logoThe cheapest trip from Medford, OR to San Francisco, US was searched and found on Oct 10, 2025 with a price of US$97

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Medford, OR to San Francisco, US, as early as possible.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Medford to San Francisco.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Medford to San Francisco, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Medford to San Francisco that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from Medford to San Francisco while indulging in miles on end of beautiful scenic views.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Will you be returning to Medford, OR by bus?

Bus from San Francisco, US to Medford, OR

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