Bus Tickets from Orlando to Knoxville (TN)

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TodayMay 23
TomorrowMay 24
SunMay 25
MonMay 26
from US$125
TueMay 27
WedMay 28
ThuMay 29
FriMay 30

Cheap buses leaving Monday

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: May 26 at
    Departure city: Orlando
    Departure location: Orlando Bus Station
    Arrival time: May 27 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: May 26 at
    Departure city: Orlando
    Departure location: Orlando Bus Station
    Arrival time: May 26 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: May 26 at
    Departure city: Orlando
    Departure location: Orlando Bus Station
    Arrival time: May 26 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: May 26 at
    Departure city: Orlando
    Departure location: Orlando Bus Station
    Arrival time: May 27 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: May 26 at
    Departure city: Orlando
    Departure location: The Florida Mall
    Arrival time: May 27 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

Last refresh of the prices: Last Tuesday at 2:48 AM EDT.

Prices and availability are subject to change.

Accepted payments

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Bus Orlando to Knoxville: Trip Overview

Average Ticket PriceUS$103
Average Bus Trip Duration1d
Number of daily buses3
Earliest bus departure5:15am
Distance860 km
Latest bus departure10:40pm

Orlando to Knoxville Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Orlando to Knoxville.

We make it our job to connect you with the most dependable bus companies that cover bus service from Orlando to Knoxville.

Whether it is cheap bus tickets or more luxurious buses going to Knoxville from Orlando, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Orlando - Knoxville (TN)

  1. How long is the bus ride from Orlando to Knoxville?

    The typical travel time from Orlando to Knoxville by bus is around 1d. The fastest bus on this trip will get to Knoxville in 16h 5m

  2. How far is Orlando from Knoxville?

    It's about 861 km (534 miles) from Orlando to Knoxville.

  3. What are the departure and arrival locations for buses traveling from Orlando to Knoxville?

    Buses departing from Orlando Bus Station in Orlando will take you to 100 Kirkwood St in Knoxville.

  4. What is the cheapest way to travel from Orlando to Knoxville?

    The least expensive option to go from Orlando to Knoxville would be going by bus. With a starting ticket price of US$78, this bus becomes your top pick for this journey.

  5. How much does it cost to take the bus from Orlando to Knoxville?

    You can expect to pay around US$103 for the bus ride from Orlando to Knoxville.

  6. Can I take an overnight bus from Orlando to Knoxville?

    Yes! If you're heading from Orlando to Knoxville, you'll find buses departing until 10:40pm and arriving the next day.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
05-21
No data
05-22
No data
Today
No data
05-24
US$84
05-25
US$91
05-26
US$136
05-27
No data
05-28
US$138
busbud logoThe cheapest trip from Orlando to Knoxville was searched and found on May 24, 2025 with a price of US$84

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Orlando to Knoxville, as early as possible.

You can expect to pay from US$84 to US$138 for a bus ticket from Orlando to Knoxville based on the last 2 days. You can expect to find the cheapest price for the trip at US$84 which is on 2025-05-24.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Orlando to Knoxville but it'll also be endearing to native speakers who will surely appreciate your effort.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Orlando to Knoxville.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Orlando to Knoxville.

Make a music playlist for your bus ride from Orlando to Knoxville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Will you be returning to Orlando by bus?

Bus from Orlando to Knoxville

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